UTY (gene)

From Wikipedia, the free encyclopedia

Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked

Identifiers

UTY; DKFZp686L12190; UTY1

External IDs

Gene ontology
Molecular Function:	• molecular_function • binding
Cellular Component:	• cellular_component • nucleus
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_007125 (mRNA)
NP_009056 (protein)

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n/a (protein)

Location

Chr Y: 13.87 - 14.1 Mb

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Pubmed search

[1]

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Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked, also known as UTY, is a human gene.^[1]

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked.

[edit] Further reading

Greenfield A, Scott D, Pennisi D, et al. (1997). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene.". Nat. Genet. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID 8944031.
Lahn BT, Page DC (1997). "Functional coherence of the human Y chromosome.". Science 278 (5338): 675–80. PMID 9381176.
Greenfield A, Carrel L, Pennisi D, et al. (1998). "The UTX gene escapes X inactivation in mice and humans.". Hum. Mol. Genet. 7 (4): 737–42. PMID 9499428.
Grbavec D, Lo R, Liu Y, et al. (1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.". Biochem. J. 337 ( Pt 1): 13–7. PMID 9854018.
Warren EH, Gavin MA, Simpson E, et al. (2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen.". J. Immunol. 164 (5): 2807–14. PMID 10679124.
Foresta C, Ferlin A, Moro E (2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.". Hum. Mol. Genet. 9 (8): 1161–9. PMID 10767340.
Shen P, Wang F, Underhill PA, et al. (2000). "Population genetic implications from sequence variation in four Y chromosome genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7354–9. PMID 10861003.
Vogt MH, Goulmy E, Kloosterboer FM, et al. (2000). "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition.". Blood 96 (9): 3126–32. PMID 11049993.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.". Nature 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
Gerrard DT, Filatov DA (2005). "Positive and negative selection on mammalian Y chromosomes.". Mol. Biol. Evol. 22 (6): 1423–32. doi:10.1093/molbev/msi128. PMID 15758204.