UTS2

From Wikipedia, the free encyclopedia

Urotensin 2

Identifiers

UTS2; PRO1068; U-II; UCN2; UII

External IDs

OMIM: 604097 MGI: 1346329 HomoloGene: 4939

Gene ontology
Molecular Function:	• hormone activity
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• muscle contraction • synaptic transmission • blood pressure regulation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006786 (mRNA)
NP_006777 (protein)

NM_011910 (mRNA)
NP_036040 (protein)

Location

Chr 1: 7.83 - 7.84 Mb

Chr 4: 149.84 - 149.85 Mb

Pubmed search

[1]

[2]

Urotensin 2, also known as UTS2, is a human gene.^[1]

This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: UTS2 urotensin 2.

[edit] Further reading

Zhou P, Li ZL, Tang CS (2002). "Regulative effect of human urotensin-II on cardiovascular system.". Di Yi Jun Yi Da Xue Xue Bao 22 (6): 566-8. PMID 12297490.
Maguire JJ, Davenport AP (2003). "Is urotensin-II the new endothelin?". Br. J. Pharmacol. 137 (5): 579-88. doi:10.1038/sj.bjp.0704924. PMID 12381671.
Balment RJ, Song W, Ashton N (2006). "Urotensin II: ancient hormone with new functions in vertebrate body fluid regulation.". Ann. N. Y. Acad. Sci. 1040: 66-73. doi:10.1196/annals.1327.007. PMID 15891007.
Zhu YC, Zhu YZ, Moore PK (2006). "The role of urotensin II in cardiovascular and renal physiology and diseases.". Br. J. Pharmacol. 148 (7): 884-901. doi:10.1038/sj.bjp.0706800. PMID 16783414.
Ashton N (2006). "Renal and vascular actions of urotensin II.". Kidney Int. 70 (4): 624-9. doi:10.1038/sj.ki.5001621. PMID 16807543.
Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.". Eur. J. Clin. Invest. 27 (8): 639-44. PMID 9279525.
Coulouarn Y, Lihrmann I, Jegou S, et al. (1999). "Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord.". Proc. Natl. Acad. Sci. U.S.A. 95 (26): 15803-8. PMID 9861051.
Ames RS, Sarau HM, Chambers JK, et al. (1999). "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.". Nature 401 (6750): 282-6. doi:10.1038/45809. PMID 10499587.
Liu Q, Pong SS, Zeng Z, et al. (2000). "Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14.". Biochem. Biophys. Res. Commun. 266 (1): 174-8. doi:10.1006/bbrc.1999.1796. PMID 10581185.
Zatelli MC, Tagliati F, Taylor JE, et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.". J. Clin. Endocrinol. Metab. 86 (5): 2161-9. PMID 11344221.
Matsushita M, Shichiri M, Imai T, et al. (2002). "Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues.". J. Hypertens. 19 (12): 2185-90. PMID 11725162.
Valdez GR, Inoue K, Koob GF, et al. (2002). "Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide.". Brain Res. 943 (1): 142-50. PMID 12088848.
Kinney WA, Almond Jr HR, Qi J, et al. (2002). "Structure-function analysis of urotensin II and its use in the construction of a ligand-receptor working model.". Angew. Chem. Int. Ed. Engl. 41 (16): 2940-4. doi:10.1002/1521-3773(20020816)41:16<2940::AID-ANIE2940>3.0.CO;2-M. PMID 12203418.
Dschietzig T, Bartsch C, Pregla R, et al. (2003). "Plasma levels and cardiovascular gene expression of urotensin-II in human heart failure.". Regul. Pept. 110 (1): 33-8. PMID 12468107.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhu F, Ji L, Luo B (2003). "[The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population]". Zhonghua Yi Xue Za Zhi 82 (21): 1473-5. PMID 12509909.
Russell FD, Meyers D, Galbraith AJ, et al. (2003). "Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure.". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1576-81. doi:10.1152/ajpheart.00217.2003. PMID 12791592.
Wenyi Z, Suzuki S, Hirai M, et al. (2004). "Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects.". Diabetologia 46 (7): 972-6. doi:10.1007/s00125-003-1145-1. PMID 12830381.