UTP-hexose-1-phosphate uridylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an UTP-hexose-1-phosphate uridylyltransferase (EC 2.7.7.10) is an enzyme that catalyzes the chemical reaction

UTP + alpha-D-galactose 1-phosphate diphosphate + UDP-galactose

Thus, the two substrates of this enzyme are UTP and alpha-D-galactose 1-phosphate, whereas its two products are diphosphate and UDP-galactose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:alpha-D-hexose-1-phosphate uridylyltransferase. Other names in common use include galactose-1-phosphate uridylyltransferase, galactose 1-phosphate uridylyltransferase, alpha-D-galactose 1-phosphate uridylyltransferase, galactose 1-phosphate uridyltransferase, UDPgalactose pyrophosphorylase, uridine diphosphate galactose pyrophosphorylase, and uridine diphosphogalactose pyrophosphorylase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1GUP, 1GUQ, and 1HXP.

[edit] References

• IUBMB entry for 2.7.7.10
• BRENDA references for 2.7.7.10 (Recommended.)
• PubMed references for 2.7.7.10
• PubMed Central references for 2.7.7.10
• Google Scholar references for 2.7.7.10
• ISSELBACHER KJ (1958). "A mammalian uridinediphosphate galactose pyrophosphorylase". J. Biol. Chem. 232: 429–44. PMID 13549431. 
• KALCKAR HM (1953). "The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides". Biochim. Biophys. Acta. 12: 250–64. PMID 13115434. 
• Lee L, Kimura A, Tochikura T (Tokyo). "Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum". J. Biochem.: 923–8. PMID 500588. 
• Lobelle-Rich PA, Reeves RE (1983). "Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica". Mol. Biochem. Parasitol. 7: 173–82. PMID 6304512. 

[edit] External links

The CAS registry number for this enzyme class is 9016-11-9.

• IUBMB entry for 2.7.7.10

• KEGG entry for 2.7.7.10

• BRENDA entry for 2.7.7.10

• NiceZyme view of 2.7.7.10

• EC2PDB: PDB structures for 2.7.7.10

• PRIAM entry for 2.7.7.10

• PUMA2 entry for 2.7.7.10

• IntEnz: Integrated Enzyme entry for 2.7.7.10

• MetaCyc entry for 2.7.7.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0017103: UTP:galactose-1-phosphate uridylyltransferase

• AMIGO entry for GO code 0017103: UTP:galactose-1-phosphate uridylyltransferase