USP9X

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 9, X-linked

Identifiers

USP9X; FAF; DFFRX

External IDs

OMIM: 300072 MGI: 894681 HomoloGene: 3418

Gene ontology
Molecular Function:	• cysteine-type endopeptidase activity • ubiquitin thiolesterase activity
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle • female gamete generation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001039590 (mRNA)
NP_001034679 (protein)

NM_009481 (mRNA)
NP_033507 (protein)

Location

Chr X: 40.83 - 40.98 Mb

Chr X: 12.23 - 12.34 Mb

Pubmed search

[1]

[2]

Ubiquitin specific peptidase 9, X-linked, also known as USP9X, is a human gene.^[1]

This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: USP9X ubiquitin specific peptidase 9, X-linked.

[edit] Further reading

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337-52. PMID 9827704.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Jones MH, Furlong RA, Burkin H, et al. (1997). "The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.". Hum. Mol. Genet. 5 (11): 1695-701. PMID 8922996.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Taya S, Yamamoto T, Kano K, et al. (1998). "The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme.". J. Cell Biol. 142 (4): 1053-62. PMID 9722616.
Taya S, Yamamoto T, Kanai-Azuma M, et al. (2000). "The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin.". Genes Cells 4 (12): 757-67. PMID 10620020.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Noma T, Kanai Y, Kanai-Azuma M, et al. (2003). "Stage- and sex-dependent expressions of Usp9x, an X-linked mouse ortholog of Drosophila Fat facets, during gonadal development and oogenesis in mice.". Gene Expr. Patterns 2 (1-2): 87-91. PMID 12617843.
Murray RZ, Jolly LA, Wood SA (2004). "The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin.". Mol. Biol. Cell 15 (4): 1591-9. doi:10.1091/mbc.E03-08-0630. PMID 14742711.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205-10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.". J. Cell. Sci. 118 (Pt 23): 5661-73. doi:10.1242/jcs.02670. PMID 16306228.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Mouchantaf R, Azakir BA, McPherson PS, et al. (2007). "The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X.". J. Biol. Chem. 281 (50): 38738-47. doi:10.1074/jbc.M605959200. PMID 17038327.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.