USP8

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Ubiquitin specific peptidase 8
PDB rendering based on 1whb.
Available structures: 1whb, 2a9u, 2gfo, 2gwf
Identifiers
Symbol(s) USP8; FLJ34456; HumORF8; KIAA0055; MGC129718; UBPY
External IDs OMIM: 603158 MGI: 1934029 HomoloGene: 3782
Orthologs
Human Mouse
Entrez 9101 84092
Ensembl n/a ENSMUSG00000027363
Uniprot n/a Q3TQM7
Refseq NM_005154 (mRNA)
NP_005145 (protein)		 NM_019729 (mRNA)
NP_062703 (protein)
Location n/a Chr 2: 126.4 - 126.45 Mb
Pubmed search [1] [2]

Ubiquitin specific peptidase 8, also known as USP8, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: USP8 ubiquitin specific peptidase 8.

[edit] Further reading

  • D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. PMID 9827704. 
  • Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. 
  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. PMID 7584044. 
  • Janssen JW, Schleithoff L, Bartram CR, Schulz AS (1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.". Oncogene 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025. 
  • Naviglio S, Mattecucci C, Matoskova B, et al. (1998). "UBPY: a growth-regulated human ubiquitin isopeptidase.". EMBO J. 17 (12): 3241–50. doi:10.1093/emboj/17.12.3241. PMID 9628861. 
  • Kato M, Miyazawa K, Kitamura N (2001). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.". J. Biol. Chem. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817. 
  • Gnesutta N, Ceriani M, Innocenti M, et al. (2001). "Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1.". J. Biol. Chem. 276 (42): 39448–54. doi:10.1074/jbc.M103454200. PMID 11500497. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kaneko T, Kumasaka T, Ganbe T, et al. (2004). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain.". J. Biol. Chem. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930. 
  • Soares L, Seroogy C, Skrenta H, et al. (2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL.". Nat. Immunol. 5 (1): 45–54. doi:10.1038/ni1017. PMID 14661020. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Wu X, Yen L, Irwin L, et al. (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMID 15314180. 
  • Berruti G, Martegani E (2005). "The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells.". Biol. Reprod. 72 (1): 14–21. doi:10.1095/biolreprod.104.030866. PMID 15342353. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. 
  • Row PE, Prior IA, McCullough J, et al. (2006). "The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation.". J. Biol. Chem. 281 (18): 12618–24. doi:10.1074/jbc.M512615200. PMID 16520378. 
  • Mizuno E, Kobayashi K, Yamamoto A, et al. (2006). "A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes.". Traffic 7 (8): 1017–31. doi:10.1111/j.1600-0854.2006.00452.x. PMID 16771824. 
  • Avvakumov GV, Walker JR, Xue S, et al. (2007). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).". J. Biol. Chem. 281 (49): 38061–70. doi:10.1074/jbc.M606704200. PMID 17035239. 
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