USP5

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 5 (isopeptidase T)

PDB rendering based on 2dag.

Available structures: 2dag, 2dak, 2g43, 2g45

Identifiers

Symbol(s)

USP5; ISOT

External IDs

OMIM: 601447 MGI: 1347343 HomoloGene: 55758

Gene ontology
Molecular Function:	• cysteine-type endopeptidase activity • protein binding • zinc ion binding • ubiquitin-specific protease 5 activity • metal ion binding
Cellular Component:	• proteasome complex (sensu Eukaryota) • lysosome
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003481 (mRNA)
NP_003472 (protein)

NM_013700 (mRNA)
NP_038728 (protein)

Location

Chr 12: 6.83 - 6.85 Mb

Chr 6: 124.78 - 124.8 Mb

Pubmed search

[1]

[2]

Ubiquitin specific peptidase 5 (isopeptidase T), also known as USP5, is a human gene.^[1]

[edit] References

^ Entrez Gene: USP5 ubiquitin specific peptidase 5 (isopeptidase T).

[edit] Further reading

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337-52. PMID 9827704.
Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544-58. doi:10.1038/nrg1111. PMID 12838346.
Falquet L, Paquet N, Frutiger S, et al. (1996). "cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2).". FEBS Lett. 376 (3): 233-7. PMID 7498549.
Wilkinson KD, Tashayev VL, O'Connor LB, et al. (1995). "Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T.". Biochemistry 34 (44): 14535-46. PMID 7578059.
Falquet L, Paquet N, Frutiger S, et al. (1995). "A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro.". FEBS Lett. 359 (1): 73-7. PMID 7851534.
Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.". Genome Res. 6 (4): 314-26. PMID 8723724.
Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.". Genome Res. 7 (3): 268-80. PMID 9074930.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677-84. doi:10.1101/gr.164001. PMID 11337467.
Engidawork E, Juranville JF, Fountoulakis M, et al. (2002). "Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome.". J. Neural Transm. Suppl. (61): 117-30. PMID 11771738.
Gabriel JM, Lacombe T, Carobbio S, et al. (2002). "Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T.". Biochemistry 41 (46): 13755-66. PMID 12427038.
Lacombe T, Gabriel JM (2002). "Further characterization of the putative human isopeptidase T catalytic site.". FEBS Lett. 531 (3): 469-74. PMID 12435595.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311-26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Reyes-Turcu FE, Horton JR, Mullally JE, et al. (2006). "The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin.". Cell 124 (6): 1197-208. doi:10.1016/j.cell.2006.02.038. PMID 16564012.