USP4

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 4 (proto-oncogene)

Identifiers

USP4; MGC149848; MGC149849; UNP; Unph

External IDs

OMIM: 603486 MGI: 98905 HomoloGene: 20716

Gene ontology
Molecular Function:	• cysteine-type endopeptidase activity • ubiquitin thiolesterase activity • peptidase activity
Cellular Component:	• nucleus • lysosome
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003363 (mRNA)
NP_003354 (protein)

NM_011678 (mRNA)
NP_035808 (protein)

Location

Chr 3: 49.29 - 49.35 Mb

Chr 9: 108.21 - 108.25 Mb

Pubmed search

[1]

[2]

Ubiquitin specific peptidase 4 (proto-oncogene), also known as USP4, is a human gene.^[1]

[edit] References

^ Entrez Gene: USP4 ubiquitin specific peptidase 4 (proto-oncogene).

[edit] Further reading

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337-52. PMID 9827704.
Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544-58. doi:10.1038/nrg1111. PMID 12838346.
Gray DA, Inazawa J, Gupta K, et al. (1995). "Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors.". Oncogene 10 (11): 2179-83. PMID 7784062.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Gupta K, Chevrette M, Gray DA (1994). "The Unp proto-oncogene encodes a nuclear protein.". Oncogene 9 (6): 1729-31. PMID 8183569.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Frederick A, Rolfe M, Chiu MI (1998). "The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines.". Oncogene 16 (2): 153-65. doi:10.1038/sj.onc.1201537. PMID 9464533.
Di Donato F, Chan EK, Askanase AD, et al. (2001). "Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function.". Int. J. Biochem. Cell Biol. 33 (9): 924-34. PMID 11461834.
Blanchette P, Gilchrist CA, Baker RT, Gray DA (2001). "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130.". Oncogene 20 (39): 5533-7. doi:10.1038/sj.onc.1204823. PMID 11571651.
DeSalle LM, Latres E, Lin D, et al. (2001). "The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein.". Oncogene 20 (39): 5538-42. doi:10.1038/sj.onc.1204824. PMID 11571652.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wada K, Tanji K, Kamitani T (2006). "Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.". Biochem. Biophys. Res. Commun. 339 (3): 731-6. doi:10.1016/j.bbrc.2005.11.076. PMID 16316627.
Wada K, Kamitani T (2006). "UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself.". Biochem. Biophys. Res. Commun. 342 (1): 253-8. doi:10.1016/j.bbrc.2006.01.144. PMID 16472766.