USP48

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 48

Identifiers

USP48; RAP1GA1; USP31; DKFZp762M1713; MGC132556; MGC14879

External IDs

Gene ontology
Molecular Function:	• ubiquitin thiolesterase activity • cysteine-type peptidase activity
Cellular Component:	• nucleus
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001032730 (mRNA)
NP_001027902 (protein)

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n/a (protein)

Location

Chr 1: 21.88 - 21.98 Mb

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Pubmed search

[1]

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Ubiquitin specific peptidase 48, also known as USP48, is a human gene.^[1]

This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: USP48 ubiquitin specific peptidase 48.

[edit] Further reading

Wilkinson KD (1998). "Regulation of ubiquitin-dependent processes by deubiquitinating enzymes.". FASEB J. 11 (14): 1245–56. PMID 9409543.
Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.". Biochem. Biophys. Res. Commun. 314 (1): 54–62. PMID 14715245.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Lockhart PJ, Hulihan M, Lincoln S, et al. (2004). "Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis.". DNA Seq. 15 (1): 9–14. PMID 15354349.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Tzimas C, Michailidou G, Arsenakis M, et al. (2006). "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.". Cell. Signal. 18 (1): 83–92. doi:10.1016/j.cellsig.2005.03.017. PMID 16214042.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.