USP20

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 20

Identifiers

USP20; KIAA1003; LSFR3A; VDU2

External IDs

MGI: 1921520 HomoloGene: 4861

Gene ontology
Molecular Function:	• ubiquitin thiolesterase activity • cysteine-type peptidase activity • zinc ion binding • metal ion binding
Cellular Component:	• cellular_component
Biological Process:	• ubiquitin-dependent protein catabolic process • protein deubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001008563 (mRNA)
NP_001008563 (protein)

NM_028846 (mRNA)
NP_083122 (protein)

Location

Chr 9: 131.64 - 131.68 Mb

Chr 2: 30.8 - 30.85 Mb

Pubmed search

[1]

[2]

Ubiquitin specific peptidase 20, also known as USP20, is a human gene.^[1]

[edit] References

^ Entrez Gene: USP20 ubiquitin specific peptidase 20.

[edit] Further reading

Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544-58. doi:10.1038/nrg1111. PMID 12838346.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63-70. PMID 10231032.
Gilley J, Fried M (1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes.". Hum. Mol. Genet. 8 (7): 1313-20. PMID 10369878.
Li Z, Wang D, Na X, et al. (2002). "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.". Biochem. Biophys. Res. Commun. 294 (3): 700-9. doi:10.1016/S0006-291X(02)00534-X. PMID 12056827.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Curcio-Morelli C, Zavacki AM, Christofollete M, et al. (2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.". J. Clin. Invest. 112 (2): 189-96. doi:10.1172/JCI200318348. PMID 12865408.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Li Z, Wang D, Messing EM, Wu G (2005). "VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.". EMBO Rep. 6 (4): 373-8. doi:10.1038/sj.embor.7400377. PMID 15776016.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.