USP18

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 18

Identifiers

USP18; ISG43; UBP43

External IDs

OMIM: 607057 MGI: 1344364 HomoloGene: 8047

Gene ontology
Molecular Function:	• ubiquitin thiolesterase activity • cysteine-type peptidase activity
Cellular Component:	• nucleus
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001128928 (mRNA)
XP_001128928 (protein)

XM_001002847 (mRNA)
XP_001002847 (protein)

Location

Chr 22: 17.01 - 17.04 Mb

Chr 6: 121.21 - 121.24 Mb

Pubmed search

[1]

[2]

Ubiquitin specific peptidase 18, also known as USP18, is a human gene.^[1]

USP18, a member of the deubiquitinating protease family of enzymes, removes ubiquitin adducts from a broad range of protein substrates.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: USP18 ubiquitin specific peptidase 18.

[edit] Further reading

Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544-58. doi:10.1038/nrg1111. PMID 12838346.
Li XL, Blackford JA, Judge CS, et al. (2000). "RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response.". J. Biol. Chem. 275 (12): 8880-8. PMID 10722734.
Schwer H, Liu LQ, Zhou L, et al. (2000). "Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18).". Genomics 65 (1): 44-52. doi:10.1006/geno.2000.6148. PMID 10777664.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Kang D, Jiang H, Wu Q, et al. (2001). "Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH.". Gene 267 (2): 233-42. PMID 11313150.
Malakhov MP, Malakhova OA, Kim KI, et al. (2002). "UBP43 (USP18) specifically removes ISG15 from conjugated proteins.". J. Biol. Chem. 277 (12): 9976-81. doi:10.1074/jbc.M109078200. PMID 11788588.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tokarz S, Berset C, La Rue J, et al. (2004). "The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.". J. Biol. Chem. 279 (45): 46424-30. doi:10.1074/jbc.M403189200. PMID 15342634.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Yan M, Luo JK, Ritchie KJ, et al. (2007). "Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.". Blood 110 (1): 305-12. doi:10.1182/blood-2006-07-033209. PMID 17374743.