USP14

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

PDB rendering based on 1wgg.

Available structures: 1wgg, 2ayn, 2ayo

Identifiers

Symbol(s)

USP14; TGT

External IDs

OMIM: 607274 MGI: 1928898 HomoloGene: 3780

Gene ontology
Molecular Function:	• cysteine-type endopeptidase activity • ubiquitin thiolesterase activity • tRNA guanylyltransferase activity
Cellular Component:	• soluble fraction • synaptosome
Biological Process:	• protein modification process • ubiquitin-dependent protein catabolic process • ubiquitin cycle • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001037334 (mRNA)
NP_001032411 (protein)

NM_001038589 (mRNA)
NP_001033678 (protein)

Location

Chr 18: 0.15 - 0.2 Mb

Chr 18: 10 - 10.02 Mb

Pubmed search

[1]

[2]

Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase), also known as USP14, is a human gene.^[1]

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase).

[edit] Further reading

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337-52. PMID 9827704.
Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544-58. doi:10.1038/nrg1111. PMID 12838346.
Deshpande KL, Seubert PH, Tillman DM, et al. (1996). "Cloning and characterization of cDNA encoding the rabbit tRNA-guanine transglycosylase 60-kilodalton subunit.". Arch. Biochem. Biophys. 326 (1): 1-7. doi:10.1006/abbi.1996.0039. PMID 8579355.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.". Exp. Cell Res. 289 (2): 211-21. PMID 14499622.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Dennehey BK, Gutches DG, McConkey EH, Krauter KS (2004). "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution.". Genomics 83 (3): 493-501. doi:10.1016/j.ygeno.2003.08.017. PMID 14962675.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hu M, Li P, Song L, et al. (2005). "Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.". EMBO J. 24 (21): 3747-56. doi:10.1038/sj.emboj.7600832. PMID 16211010.
Shinji S, Naito Z, Ishiwata S, et al. (2006). "Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases.". Oncol. Rep. 15 (3): 539-43. PMID 16465409.
Crimmins S, Jin Y, Wheeler C, et al. (2006). "Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14.". J. Neurosci. 26 (44): 11423-31. doi:10.1523/JNEUROSCI.3600-06.2006. PMID 17079671.