USP11

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 11

Identifiers

External IDs

OMIM: 300050 MGI: 2384312 HomoloGene: 31252

Gene ontology
Molecular Function:	• cysteine-type endopeptidase activity • ubiquitin thiolesterase activity • peptidase activity
Cellular Component:	• nucleus
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

Orthologs

Human

Mouse

Refseq

NM_004651 (mRNA)
NP_004642 (protein)

NM_145628 (mRNA)
NP_663603 (protein)

Location

Chr X: 46.98 - 46.99 Mb

Chr X: 19.86 - 19.88 Mb

Pubmed search

[1]

[2]

Ubiquitin specific peptidase 11, also known as USP11, is a human gene.^[1]

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23^[1]

[edit] References

^ ^a ^b Entrez Gene: USP11 ubiquitin specific peptidase 11.

[edit] Further reading

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337-52. PMID 9827704.
Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544-58. doi:10.1038/nrg1111. PMID 12838346.
Swanson DA, Freund CL, Ploder L, et al. (1996). "A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders.". Hum. Mol. Genet. 5 (4): 533-8. PMID 8845848.
Brandau O, Nyakatura G, Jedele KB, et al. (1999). "UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2.". Eur. J. Hum. Genet. 6 (5): 459-66. doi:10.1038/sj.ejhg.5200207. PMID 9801870.
Stoddart KL, Jermak C, Nagaraja R, et al. (1999). "Physical map covering a 2 Mb region in human xp11.3 distal to DX6849.". Gene 227 (1): 111-6. PMID 9931462.
Thiselton DL, McDowall J, Brandau O, et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders.". Genomics 79 (4): 560-72. doi:10.1006/geno.2002.6733. PMID 11944989.
Ideguchi H, Ueda A, Tanaka M, et al. (2003). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM.". Biochem. J. 367 (Pt 1): 87-95. doi:10.1042/BJ20011851. PMID 12084015.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Angelats C, Wang XW, Jermiin LS, et al. (2003). "Isolation and characterization of the mouse ubiquitin-specific protease Usp15.". Mamm. Genome 14 (1): 31-46. doi:10.1007/s00335-002-3035-0. PMID 12532266.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Schoenfeld AR, Apgar S, Dolios G, et al. (2004). "BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage.". Mol. Cell. Biol. 24 (17): 7444-55. doi:10.1128/MCB.24.17.7444-7455.2004. PMID 15314155.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.