USO1

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Vesicle docking protein p115

Identifiers

VDP; TAP; P115

External IDs

OMIM: 603344 MGI: 1929095 HomoloGene: 2754

Gene ontology
Molecular Function:	• binding • protein transporter activity
Cellular Component:	• Golgi membrane • cytoplasm • membrane
Biological Process:	• intracellular protein transport • ER to Golgi vesicle-mediated transport • vesicle docking during exocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003715 (mRNA)
NP_003706 (protein)

NM_019490 (mRNA)
NP_062363 (protein)

Location

Chr 4: 76.87 - 76.95 Mb

Chr 5: 93.21 - 93.28 Mb

Pubmed search

[1]

[2]

Vesicle docking protein p115, also known as VDP, is a human gene.^[1]

The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GM130 and giantin in a sequential manner.^[1]

[edit] References

^ ^a ^b Entrez Gene: VDP vesicle docking protein p115.

[edit] Further reading

Whyte JR, Munro S (2002). "Vesicle tethering complexes in membrane traffic.". J. Cell. Sci. 115 (Pt 13): 2627–37. PMID 12077354.
Short B, Haas A, Barr FA (2005). "Golgins and GTPases, giving identity and structure to the Golgi apparatus.". Biochim. Biophys. Acta 1744 (3): 383–95. doi:10.1016/j.bbamcr.2005.02.001. PMID 15979508.
Waters MG, Clary DO, Rothman JE (1992). "A novel 115-kD peripheral membrane protein is required for intercisternal transport in the Golgi stack.". J. Cell Biol. 118 (5): 1015–26. PMID 1512287.
Nakamura N, Lowe M, Levine TP, et al. (1997). "The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner.". Cell 89 (3): 445–55. PMID 9150144.
Sohda M, Misumi Y, Yano A, et al. (1998). "Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane.". J. Biol. Chem. 273 (9): 5385–8. PMID 9478999.
Barr FA, Nakamura N, Warren G (1998). "Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae.". EMBO J. 17 (12): 3258–68. doi:10.1093/emboj/17.12.3258. PMID 9628863.
Nelson DS, Alvarez C, Gao YS, et al. (1998). "The membrane transport factor TAP/p115 cycles between the Golgi and earlier secretory compartments and contains distinct domains required for its localization and function.". J. Cell Biol. 143 (2): 319–31. PMID 9786945.
Allan BB, Moyer BD, Balch WE (2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion.". Science 289 (5478): 444–8. PMID 10903204.
Dirac-Svejstrup AB, Shorter J, Waters MG, Warren G (2000). "Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments.". J. Cell Biol. 150 (3): 475–88. PMID 10931861.
Alvarez C, Garcia-Mata R, Hauri HP, Sztul E (2001). "The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic.". J. Biol. Chem. 276 (4): 2693–700. doi:10.1074/jbc.M007957200. PMID 11035033.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Brunati AM, Marin O, Folda A, et al. (2001). "Possible implication of the Golgi apparatus casein kinase in the phosphorylation of vesicle docking protein p115 Ser-940: a study with peptide substrates.". Biochem. Biophys. Res. Commun. 284 (3): 817–22. doi:10.1006/bbrc.2001.5049. PMID 11396975.
Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMID 11927603.
Short B, Preisinger C, Schaletzky J, et al. (2003). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.". Curr. Biol. 12 (20): 1792–5. PMID 12401177.
Chiu R, Novikov L, Mukherjee S, Shields D (2003). "A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis.". J. Cell Biol. 159 (4): 637–48. doi:10.1083/jcb.200208013. PMID 12438416.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Han SJ, Lee JH, Kim CG, Hong SH (2003). "Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport.". Biochem. Biophys. Res. Commun. 300 (3): 649–55. PMID 12507498.
García-Mata R, Sztul E (2003). "The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor.". EMBO Rep. 4 (3): 320–5. doi:10.1038/sj.embor.embor762. PMID 12634853.