Uridine nucleosidase

From Wikipedia, the free encyclopedia

In enzymology, an uridine nucleosidase (EC 3.2.2.3) is an enzyme that catalyzes the chemical reaction

uridine + H₂O D-ribose + uracil

Thus, the two substrates of this enzyme are uridine and H₂O, whereas its two products are D-ribose and uracil.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is uridine ribohydrolase. This enzyme is also called uridine hydrolase. This enzyme participates in pyrimidine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes 1EMH, 1EMJ, 1EUG, 1FLZ, 1OKB, 1SSP, 1UDG, 1UDH, 1UDI, 1UGH, 1UUG, 1YUO, 2BOO, 2C53, 2C56, 2EUG, 2J8X, 2SSP, 2UUG, 3EUG, 4EUG, 4SKN, and 5EUG.

[edit] References

• IUBMB entry for 3.2.2.3
• BRENDA references for 3.2.2.3 (Recommended.)
• PubMed references for 3.2.2.3
• PubMed Central references for 3.2.2.3
• Google Scholar references for 3.2.2.3
• Carter CE (1951). "Partial purification of a non-phosphorylytic uridine nucleosidase from yeast". J. Am. Chem. Soc. 73: 1508–1510. doi:10.1021/ja01148a028. 

[edit] External links

The CAS registry number for this enzyme class is 9025-47-2.

• IUBMB entry for 3.2.2.3

• KEGG entry for 3.2.2.3

• BRENDA entry for 3.2.2.3

• NiceZyme view of 3.2.2.3

• EC2PDB: PDB structures for 3.2.2.3

• PRIAM entry for 3.2.2.3

• PUMA2 entry for 3.2.2.3

• IntEnz: Integrated Enzyme entry for 3.2.2.3

• MetaCyc entry for 3.2.2.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0045437: uridine nucleosidase

• AMIGO entry for GO code 0045437: uridine nucleosidase