Ureidoglycolate hydrolase

From Wikipedia, the free encyclopedia

In enzymology, an ureidoglycolate hydrolase (EC 3.5.3.19) is an enzyme that catalyzes the chemical reaction

(S)-ureidoglycolate + H₂O glyoxylate + 2 NH₃ + CO₂

Thus, the two substrates of this enzyme are (S)-ureidoglycolate and H₂O, whereas its 3 products are glyoxylate, NH₃, and CO₂.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is (S)-ureidoglycolate amidohydrolase (decarboxylating). This enzyme participates in purine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1XSQ, 1XSR, 1YQC, and 2BDR.

[edit] References

• IUBMB entry for 3.5.3.19
• BRENDA references for 3.5.3.19 (Recommended.)
• PubMed references for 3.5.3.19
• PubMed Central references for 3.5.3.19
• Google Scholar references for 3.5.3.19
• Winkler RG, Blevins DG and Randall DD (1988). "Ureide catabolism in soybeans. III. Ureidoglycolate amidohydrolase and allantoate amidohydrolase are activities of an allantoate degrading enzyme complex". Plant Physiol. 86: 1084–1088. 

[edit] External links

The CAS registry number for this enzyme class is 115629-07-7.

• IUBMB entry for 3.5.3.19

• KEGG entry for 3.5.3.19

• BRENDA entry for 3.5.3.19

• NiceZyme view of 3.5.3.19

• EC2PDB: PDB structures for 3.5.3.19

• PRIAM entry for 3.5.3.19

• PUMA2 entry for 3.5.3.19

• IntEnz: Integrated Enzyme entry for 3.5.3.19

• MetaCyc entry for 3.5.3.19

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004848: ureidoglycolate hydrolase

• AMIGO entry for GO code 0004848: ureidoglycolate hydrolase