Urea carboxylase

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In enzymology, an urea carboxylase (EC 6.3.4.6) is an enzyme that catalyzes the chemical reaction

ATP + urea + HCO₃- $\rightleftharpoons$ ADP + phosphate + urea-1-carboxylate

The 3 substrates of this enzyme are ATP, urea, and HCO3-, whereas its 3 products are ADP, phosphate, and urea-1-carboxylate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is urea:carbon-dioxide ligase (ADP-forming). Other names in common use include urease (ATP-hydrolysing), urea carboxylase (hydrolysing), ATP-urea amidolyase, urea amidolyase, UALase, and UCA. This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, biotin.

[edit] References

IUBMB entry for 6.3.4.6
BRENDA references for 6.3.4.6 (Recommended.)
PubMed references for 6.3.4.6
PubMed Central references for 6.3.4.6
Google Scholar references for 6.3.4.6
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Sumrada RA, Cooper TG (1982). "Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast". J. Biol. Chem. 257: 9119–27. PMID 6124544.
Kanamori T, Kanou N, Atomi H, Imanaka T (2004). "Enzymatic characterization of a prokaryotic urea carboxylase". J. Bacteriol. 186: 2532–9. doi:10.1128/JB.186.9.2532-2539.2004. PMID 15090492.