Uracilylalanine synthase

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In enzymology, an uracilylalanine synthase (EC 2.5.1.53) is an enzyme that catalyzes the chemical reaction

O₃-acetyl-L-serine + uracil $\rightleftharpoons$ 3-(uracil-1-yl)-L-alanine + acetate

Thus, the two substrates of this enzyme are O3-acetyl-L-serine and uracil, whereas its two products are 3-(uracil-1-yl)-L-alanine and acetate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase. Other names in common use include O3-acetyl-L-serine acetate-lyase (adding uracil), isowillardiine synthase, willardiine synthase, and 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase.

[edit] References

IUBMB entry for 2.5.1.53
BRENDA references for 2.5.1.53 (Recommended.)
PubMed references for 2.5.1.53
PubMed Central references for 2.5.1.53
Google Scholar references for 2.5.1.53
Ahmmad MAS, Maskall CS and Brown EG (1984). "Partial-purification and properties of willardiine and synthase activity from Pisum sativum". Phytochemistry 23: 265–270.
Ikegami F, Kaneko M, Lambein F, Kuo, Y-H and Murakoshi I (1987). "Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum". Phytochemistry 26: 2699–2704.
Kuo, Y-H and Lambein F (1978). "Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants". Phytochemistry 17: 1571–1576.