UQCRC1

From Wikipedia, the free encyclopedia

Ubiquinol-cytochrome c reductase core protein I

PDB rendering based on 1be3.

Available structures: 1be3, 1bgy, 1l0l, 1l0n, 1ntk, 1ntm, 1ntz, 1nu1, 1pp9, 1ppj, 1qcr, 1sqq, 1sqv, 1sqx, 2a06, 2fyu

Identifiers

Symbol(s)

UQCRC1; D3S3191

External IDs

OMIM: 191328 MGI: 107876 HomoloGene: 2525

Gene ontology
Molecular Function:	• ubiquinol-cytochrome-c reductase activity • oxidoreductase activity
Cellular Component:	• mitochondrion • mitochondrial respiratory chain • membrane
Biological Process:	• electron transport • oxidative phosphorylation • transport • aerobic respiration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003365 (mRNA)
NP_003356 (protein)

NM_025407 (mRNA)
NP_079683 (protein)

Location

Chr 3: 48.61 - 48.62 Mb

Chr 9: 108.79 - 108.81 Mb

Pubmed search

[1]

[2]

Ubiquinol-cytochrome c reductase core protein I, also known as UQCRC1, is a human gene.^[1]

[edit] References

^ Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I.

[edit] Further reading

Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1991). "Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system.". J. Biol. Chem. 266 (4): 2333–8. PMID 1846623.
Broger C, Nałecz MJ, Azzi A (1980). "Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain.". Biochim. Biophys. Acta 592 (3): 519–27. PMID 6251869.
Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase.". Biochem. Mol. Biol. Int. 33 (2): 410. PMID 7951059.
Islam MM, Tanaka M, Suzuki H, et al. (1995). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase.". Biochem. Mol. Biol. Int. 33 (4): 815. PMID 7981668.
Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase.". Biochem. Mol. Biol. Int. 32 (5): 797–805. PMID 8069229.
Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993.". Electrophoresis 14 (11): 1216–22. PMID 8313870.
Hoffman GG, Lee S, Christiano AM, et al. (1993). "Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase.". J. Biol. Chem. 268 (28): 21113–9. PMID 8407948.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency.". Hum. Genet. 104 (6): 460–6. PMID 10453733.
Hu WH, Hausmann ON, Yan MS, et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP).". J. Neurochem. 81 (1): 36–45. PMID 12067236.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMID 15242332.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection.". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kulawiec M, Arnouk H, Desouki MM, et al. (2007). "Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer.". Cancer Biol. Ther. 5 (8): 967–75. PMID 16775426.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.