UQCRB

From Wikipedia, the free encyclopedia

Ubiquinol-cytochrome c reductase binding protein

Identifiers

UQCRB; QP-C; QPC; UQBC; UQBP; UQPC

External IDs

OMIM: 191330 MGI: 3646665 HomoloGene: 38164

Gene ontology
Molecular Function:	• ubiquinol-cytochrome-c reductase activity • oxidoreductase activity
Cellular Component:	• mitochondrion • mitochondrial respiratory chain • membrane
Biological Process:	• oxidative phosphorylation • mitochondrial electron transport, ubiquinol to cytochrome c • transport • aerobic respiration

Orthologs

Human

Mouse

Entrez

7381

432822

Refseq

NM_006294 (mRNA)
NP_006285 (protein)

XM_484346 (mRNA)
XP_484346 (protein)

Pubmed search

[1]

[2]

Ubiquinol-cytochrome c reductase binding protein, also known as UQCRB, is a human gene.^[1]

The ubiquinone-binding protein is a nucleus-encoded component of ubiquinol-cytochrome c oxidoreductase (Complex III; EC 1.10.2.2) in the mitochondrial respiratory chain and plays an important role in electron transfer as a complex of ubiquinone and QP-C. Complex III consists of 10 nuclear-encoded subunits and 1 mitochondrial-encoded subunit (cytochrome b; MIM 516020).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: UQCRB ubiquinol-cytochrome c reductase binding protein.

[edit] Further reading

Suzuki H, Hosokawa Y, Toda H, et al. (1990). "Common protein-binding sites in the 5'-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein.". J. Biol. Chem. 265 (14): 8159-63. PMID 2159470.
Hosokawa Y, Suzuki H, Nishikimi M, et al. (1990). "Chromosomal assignment of the gene for the ubiquinone-binding protein of human mitochondrial cytochrome bc1 complex.". Biochem. Int. 21 (1): 41-4. PMID 2167087.
Suzuki H, Hosokawa Y, Toda H, et al. (1989). "Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain.". Biochem. Biophys. Res. Commun. 161 (1): 371-8. PMID 2543413.
Wakabayashi S, Takao T, Shimonishi Y, et al. (1985). "Complete amino acid sequence of the ubiquinone binding protein (QP-C), a protein similar to the 14,000-dalton subunit of the yeast ubiquinol-cytochrome c reductase complex.". J. Biol. Chem. 260 (1): 337-43. PMID 2981208.
Suzuki H, Hosokawa Y, Toda H, et al. (1988). "Cloning and sequencing of a cDNA for human mitochondrial ubiquinone-binding protein of complex III.". Biochem. Biophys. Res. Commun. 156 (2): 987-94. PMID 3056408.
Malaney S, Heng HH, Tsui LC, et al. (1996). "Localization of the human gene encoding the 13.3-kDa subunit of mitochondrial complex III (UQCRB) to 8q22 by in situ hybridization.". Cytogenet. Cell Genet. 73 (4): 297-9. PMID 8751380.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Haut S, Brivet M, Touati G, et al. (2003). "A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis.". Hum. Genet. 113 (2): 118-22. doi:10.1007/s00439-003-0946-0. PMID 12709789.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.