UPK2

From Wikipedia, the free encyclopedia

Uroplakin 2

Identifiers

UPK2; MGC138598

External IDs

Gene ontology
Cellular Component:	• endoplasmic reticulum • integral to plasma membrane • membrane • integral to endoplasmic reticulum membrane
Biological Process:	• multicellular organismal development • membrane organization and biogenesis • epithelial cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006760 (mRNA)
NP_006751 (protein)

NM_009476 (mRNA)
NP_033502 (protein)

Location

Chr 11: 118.33 - 118.33 Mb

Chr 9: 44.2 - 44.21 Mb

Pubmed search

[1]

[2]

Uroplakin 2, also known as UPK2, is a human gene.^[1]

[edit] References

^ Entrez Gene: UPK2 uroplakin 2.

[edit] Further reading

Lin JH, Wu XR, Kreibich G, Sun TT (1994). "Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane.". J. Biol. Chem. 269 (3): 1775–84. PMID 7507484.
Wu XR, Lin JH, Walz T, et al. (1994). "Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins.". J. Biol. Chem. 269 (18): 13716–24. PMID 8175808.
Wu RL, Osman I, Wu XR, et al. (1998). "Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation.". Cancer Res. 58 (6): 1291–7. PMID 9515818.
Lobban ED, Smith BA, Hall GD, et al. (1998). "Uroplakin gene expression by normal and neoplastic human urothelium.". Am. J. Pathol. 153 (6): 1957–67. PMID 9846985.
Yuasa T, Yoshiki T, Isono T, et al. (1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients.". Int. J. Urol. 6 (6): 286–92. PMID 10404304.
Li SM, Zhang ZT, Chan S, et al. (1999). "Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder.". J. Urol. 162 (3 Pt 1): 931–5. PMID 10458411.
Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract.". Am. J. Pathol. 155 (4): 1047–50. PMID 10514386.
Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum.". Mol. Biol. Cell 13 (12): 4221–30. doi:10.1091/mbc.E02-04-0211. PMID 12475947.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hirata H, Hisatomi H, Kawakita M, et al. (2004). "Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction.". Oncol. Rep. 10 (4): 963–6. PMID 12792753.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chen F, Zeng F, Tong Q, et al. (2006). "Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector.". J. Huazhong Univ. Sci. Technol. Med. Sci. 25 (2): 188–90, 211. PMID 16116969.
Jenkins D, Bitner-Glindzicz M, Malcolm S, et al. (2007). "Mutation analyses of Uroplakin II in children with renal tract malformations.". Nephrol. Dial. Transplant. 21 (12): 3415–21. doi:10.1093/ndt/gfl465. PMID 17012268.