UPK1A

From Wikipedia, the free encyclopedia

Uroplakin 1A

Identifiers

UPK1A; MGC129751; MGC129752; MGC14388; TSPAN21; UP1A; UPIA; UPKA

External IDs

Gene ontology
Molecular Function:	• protein binding • protein homodimerization activity • monosaccharide binding
Cellular Component:	• endoplasmic reticulum • plasma membrane • integral to membrane
Biological Process:	• endocytosis • signal transduction • epithelial cell differentiation • protein oligomerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007000 (mRNA)
NP_008931 (protein)

NM_026815 (mRNA)
NP_081091 (protein)

Location

Chr 19: 40.85 - 40.86 Mb

Chr 7: 30.31 - 30.32 Mb

Pubmed search

[1]

[2]

Uroplakin 1A, also known as UPK1A, is a human gene.^[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.^[1]

[edit] References

^ ^a ^b Entrez Gene: UPK1A uroplakin 1A.

[edit] Further reading

Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
Yu J, Lin JH, Wu XR, Sun TT (1994). "Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins.". J. Cell Biol. 125 (1): 171–82. PMID 8138569.
Wu XR, Medina JJ, Sun TT (1996). "Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells.". J. Biol. Chem. 270 (50): 29752–9. PMID 8530366.
Lobban ED, Smith BA, Hall GD, et al. (1998). "Uroplakin gene expression by normal and neoplastic human urothelium.". Am. J. Pathol. 153 (6): 1957–67. PMID 9846985.
Yuasa T, Yoshiki T, Isono T, et al. (1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients.". Int. J. Urol. 6 (6): 286–92. PMID 10404304.
Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract.". Am. J. Pathol. 155 (4): 1047–50. PMID 10514386.
Kageyama S, Yoshiki T, Isono T, et al. (2003). "High expression of human uroplakin Ia in urinary bladder transitional cell carcinoma.". Jpn. J. Cancer Res. 93 (5): 523–31. PMID 12036448.
Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum.". Mol. Biol. Cell 13 (12): 4221–30. doi:10.1091/mbc.E02-04-0211. PMID 12475947.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Yuasa T, Yoshiki T, Isono T, et al. (2004). "Molecular cloning and expression of uroplakins in transitional cell carcinoma.". Adv. Exp. Med. Biol. 539 (Pt A): 33–46. PMID 15088894.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hall GD, Weeks RJ, Olsburgh J, et al. (2005). "Transcriptional control of the human urothelial-specific gene, uroplakin Ia.". Biochim. Biophys. Acta 1729 (2): 126–34. doi:10.1016/j.bbaexp.2005.04.004. PMID 15913809.