Undecaprenyl-phosphate mannosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an undecaprenyl-phosphate mannosyltransferase (EC 2.4.1.54) is an enzyme that catalyzes the chemical reaction

GDP-mannose + undecaprenyl phosphate GDP + D-mannosyl-1-phosphoundecaprenol

Thus, the two substrates of this enzyme are GDP-mannose and undecaprenyl phosphate, whereas its two products are GDP and D-mannosyl-1-phosphoundecaprenol.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase. Other names in common use include guanosine diphosphomannose-undecaprenyl phosphate, mannosyltransferase, GDP mannose-undecaprenyl phosphate mannosyltransferase, and GDP-D-mannose:lipid phosphate transmannosylase. It employs one cofactor, phosphatidylglycerol.

[edit] References

• IUBMB entry for 2.4.1.54
• BRENDA references for 2.4.1.54 (Recommended.)
• PubMed references for 2.4.1.54
• PubMed Central references for 2.4.1.54
• Google Scholar references for 2.4.1.54
• Lahav M, Chiu TH, Lennarz WJ (1969). "Studies on the biosynthesis of mannan in Micrococcus lysodeikticus II. The enzymatic synthesis of mannosyl-l-phosphoryl-undecaprenol". J. Biol. Chem. 244: 5890–8. PMID 5350943. 

[edit] External links

The CAS registry number for this enzyme class is 37277-62-6.

• IUBMB entry for 2.4.1.54

• KEGG entry for 2.4.1.54

• BRENDA entry for 2.4.1.54

• NiceZyme view of 2.4.1.54

• EC2PDB: PDB structures for 2.4.1.54

• PRIAM entry for 2.4.1.54

• PUMA2 entry for 2.4.1.54

• IntEnz: Integrated Enzyme entry for 2.4.1.54

• MetaCyc entry for 2.4.1.54

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047267: undecaprenyl-phosphate mannosyltransferase

• AMIGO entry for GO code 0047267: undecaprenyl-phosphate mannosyltransferase