UNC5A

From Wikipedia, the free encyclopedia

Unc-5 homolog A (C. elegans)

Identifiers

UNC5A; FLJ16449; KIAA1976; UNC5H1

External IDs

OMIM: 607869 MGI: 894682 HomoloGene: 41474

Gene ontology
Molecular Function:	• receptor activity • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• apoptosis • signal transduction • multicellular organismal development

Orthologs

Human

Mouse

Refseq

NM_133369 (mRNA)
NP_588610 (protein)

NM_153131 (mRNA)
NP_694771 (protein)

Location

Chr 5: 176.17 - 176.24 Mb

Chr 13: 54.96 - 55.02 Mb

Pubmed search

[1]

[2]

Unc-5 homolog A (C. elegans), also known as UNC5A, is a human gene.^[1]

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: UNC5A unc-5 homolog A (C. elegans).

[edit] Further reading

Arakawa H (2005). "Netrin-1 and its receptors in tumorigenesis.". Nat. Rev. Cancer 4 (12): 978-87. doi:10.1038/nrc1504. PMID 15573119.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.". DNA Res. 8 (6): 319-27. PMID 11853319.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Williams ME, Strickland P, Watanabe K, Hinck L (2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE.". J. Biol. Chem. 278 (19): 17483-90. doi:10.1074/jbc.M300415200. PMID 12598531.
Tanikawa C, Matsuda K, Fukuda S, et al. (2003). "p53RDL1 regulates p53-dependent apoptosis.". Nat. Cell Biol. 5 (3): 216-23. doi:10.1038/ncb943. PMID 12598906.
Thiebault K, Mazelin L, Pays L, et al. (2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4173-8. doi:10.1073/pnas.0738063100. PMID 12655055.
Geisbrecht BV, Dowd KA, Barfield RW, et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin.". J. Biol. Chem. 278 (35): 32561-8. doi:10.1074/jbc.M302943200. PMID 12810718.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Llambi F, Lourenço FC, Gozuacik D, et al. (2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.". EMBO J. 24 (6): 1192-201. doi:10.1038/sj.emboj.7600584. PMID 15729359.