UNC45A

From Wikipedia, the free encyclopedia

Unc-45 homolog A (C. elegans)

PDB rendering based on 2dba.

Available structures: 2dba

Identifiers

Symbol(s)

UNC45A; FLJ10043; GC-UNC45; IRO039700; SMAP-1

External IDs

MGI: 2142246 HomoloGene: 32423

Gene ontology
Molecular Function:	• binding
Biological Process:	• protein folding • multicellular organismal development • striated muscle development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001039675 (mRNA)
NP_001034764 (protein)

NM_133952 (mRNA)
NP_598713 (protein)

Location

Chr 15: 89.27 - 89.3 Mb

Chr 7: 80.2 - 80.21 Mb

Pubmed search

[1]

[2]

Unc-45 homolog A (C. elegans), also known as UNC45A, is a human gene.^[1]

[edit] References

^ Entrez Gene: UNC45A unc-45 homolog A (C. elegans).

[edit] Further reading

Bazzaro M, Santillan A, Lin Z, et al. (2008). "Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility.". Am. J. Pathol. 171 (5): 1640-9. doi:10.2353/ajpath.2007.070325. PMID 17872978.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Chadli A, Graham JD, Abel MG, et al. (2006). "GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.". Mol. Cell. Biol. 26 (5): 1722-30. doi:10.1128/MCB.26.5.1722-1730.2006. PMID 16478993.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Price MG, Landsverk ML, Barral JM, Epstein HF (2003). "Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions.". J. Cell. Sci. 115 (Pt 21): 4013-23. PMID 12356907.