ULBP2

From Wikipedia, the free encyclopedia

UL16 binding protein 2

Identifiers

ULBP2; N2DL2; RAET1H

External IDs

Gene ontology
Molecular Function:	• MHC class I receptor activity • GPI anchor binding
Cellular Component:	• membrane • MHC class I protein complex
Biological Process:	• antigen processing and presentation • natural killer cell activation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

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Refseq

NM_025217 (mRNA)
NP_079493 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 6: 150.3 - 150.31 Mb

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Pubmed search

[1]

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UL16 binding protein 2, also known as ULBP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: ULBP2 UL16 binding protein 2.

[edit] Further reading

Cerwenka A, Lanier LL (2004). "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer.". Tissue Antigens 61 (5): 335-43. PMID 12753652.
Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.". Immunity 14 (2): 123-33. PMID 11239445.
Onda H, Ohkubo S, Shintani Y, et al. (2001). "A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers.". Biochem. Biophys. Res. Commun. 285 (2): 235-43. doi:10.1006/bbrc.2001.5149. PMID 11444831.
Steinle A, Li P, Morris DL, et al. (2001). "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family.". Immunogenetics 53 (4): 279-87. PMID 11491531.
Sutherland CL, Chalupny NJ, Schooley K, et al. (2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.". J. Immunol. 168 (2): 671-9. PMID 11777960.
Radosavljevic M, Cuillerier B, Wilson MJ, et al. (2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.". Genomics 79 (1): 114-23. doi:10.1006/geno.2001.6673. PMID 11827464.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dunn C, Chalupny NJ, Sutherland CL, et al. (2003). "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity.". J. Exp. Med. 197 (11): 1427-39. doi:10.1084/jem.20022059. PMID 12782710.
Rölle A, Mousavi-Jazi M, Eriksson M, et al. (2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein.". J. Immunol. 171 (2): 902-8. PMID 12847260.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Eleme K, Taner SB, Onfelt B, et al. (2004). "Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.". J. Exp. Med. 199 (7): 1005-10. doi:10.1084/jem.20032194. PMID 15051759.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rohner A, Langenkamp U, Siegler U, et al. (2007). "Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis.". Leuk. Res. 31 (10): 1393-402. doi:10.1016/j.leukres.2007.02.020. PMID 17391757.