UIMC1

From Wikipedia, the free encyclopedia

Ubiquitin interaction motif containing 1

Identifiers

UIMC1; RAP80; X2HRIP110

External IDs

OMIM: 609433 MGI: 103185 HomoloGene: 9455

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • negative regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016290 (mRNA)
NP_057374 (protein)

NM_011307 (mRNA)
NP_035437 (protein)

Location

Chr 5: 176.26 - 176.43 Mb

Chr 13: 55.04 - 55.11 Mb

Pubmed search

[1]

[2]

Ubiquitin interaction motif containing 1, also known as UIMC1, is a human gene.^[1]

[edit] References

^ Entrez Gene: UIMC1 ubiquitin interaction motif containing 1.

[edit] Further reading

Yan Z, Kim YS, Jetten AM (2002). "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor.". J. Biol. Chem. 277 (35): 32379–88. doi:10.1074/jbc.M203475200. PMID 12080054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis.". Biol. Reprod. 70 (1): 106–13. doi:10.1095/biolreprod.103.018465. PMID 12954732.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wang B, Matsuoka S, Ballif BA, et al. (2007). "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.". Science 316 (5828): 1194–8. doi:10.1126/science.1139476. PMID 17525340.
Sobhian B, Shao G, Lilli DR, et al. (2007). "RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.". Science 316 (5828): 1198–202. doi:10.1126/science.1139516. PMID 17525341.
Kim H, Chen J, Yu X (2007). "Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.". Science 316 (5828): 1202–5. doi:10.1126/science.1139621. PMID 17525342.
Shebzukhov YV, Koroleva EP, Khlgatian SV, et al. (2007). "RAP80/UIMC1 as cancer-associated antigen: alternative splice variants and their immunogenicity.". Cancer Lett. 255 (2): 255–62. doi:10.1016/j.canlet.2007.04.013. PMID 17562356.
Yan J, Kim YS, Yang XP, et al. (2007). "The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.". Cancer Res. 67 (14): 6647–56. doi:10.1158/0008-5472.CAN-07-0924. PMID 17621610.
Yan J, Yang XP, Kim YS, et al. (2007). "RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation.". Biochem. Biophys. Res. Commun. 362 (1): 132–8. doi:10.1016/j.bbrc.2007.07.158. PMID 17698038.