UHRF2

From Wikipedia, the free encyclopedia

Ubiquitin-like, containing PHD and RING finger domains, 2

PDB rendering based on 1wy8.

Available structures: 1wy8, 1z6u

Identifiers

Symbol(s)

UHRF2; DKFZp434B0920; DKFZp686G0837; MGC33463; NIRF; RNF107; RP11-472F14.2; URF2

External IDs

MGI: 1923718 HomoloGene: 17001

Gene ontology
Molecular Function:	• DNA binding • ubiquitin-protein ligase activity • protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • ubiquitin-dependent protein catabolic process • cell cycle • cell proliferation • cell differentiation • regulation of cell cycle • protein autoubiquitination

Orthologs

Human

Mouse

Refseq

NM_152896 (mRNA)
NP_690856 (protein)

NM_144873 (mRNA)
NP_659122 (protein)

Location

Chr 9: 6.4 - 6.5 Mb

Chr 19: 30.1 - 30.16 Mb

Pubmed search

[1]

[2]

Ubiquitin-like, containing PHD and RING finger domains, 2, also known as UHRF2, is a human gene.^[1]

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.". Oncogene 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Li Y, Mori T, Hata H, et al. (2004). "NIRF induces G1 arrest and associates with Cdk2.". Biochem. Biophys. Res. Commun. 319 (2): 464–8. doi:10.1016/j.bbrc.2004.04.190. PMID 15178429.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Mori T, Li Y, Hata H, Kochi H (2004). "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.". FEBS Lett. 557 (1-3): 209–14. PMID 14741369.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mori T, Li Y, Hata H, et al. (2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation.". Biochem. Biophys. Res. Commun. 296 (3): 530–6. PMID 12176013.