UHRF1

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Ubiquitin-like, containing PHD and RING finger domains, 1
PDB rendering based on 2faz.
Available structures: 2faz
Identifiers
Symbol(s) UHRF1; FLJ21925; ICBP90; MGC138707; Np95; RNF106
External IDs OMIM: 607990 MGI: 1338889 HomoloGene: 7866
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 29128 18140


Refseq NM_001048201 (mRNA)
NP_001041666 (protein)		 XM_972841 (mRNA)
XP_977935 (protein)
Pubmed search [1] [2]

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a human gene.[1]

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1.

[edit] Further reading

  • Ku DH, Chang CD, Koniecki J, et al. (1991). "A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor.". Cell Growth Differ. 2 (4): 179–86. PMID 1868030. 
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549. 
  • Hopfner R, Mousli M, Jeltsch JM, et al. (2000). "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression.". Cancer Res. 60 (1): 121–8. PMID 10646863. 
  • Hopfner R, Mousli M, Garnier JM, et al. (2001). "Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression.". Gene 266 (1-2): 15–23. PMID 11290415. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mousli M, Hopfner R, Abbady AQ, et al. (2003). "ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells.". Br. J. Cancer 89 (1): 120–7. doi:10.1038/sj.bjc.6601068. PMID 12838312. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Citterio E, Papait R, Nicassio F, et al. (2004). "Np95 is a histone-binding protein endowed with ubiquitin ligase activity.". Mol. Cell. Biol. 24 (6): 2526–35. PMID 14993289. 
  • Arima Y, Hirota T, Bronner C, et al. (2004). "Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition.". Genes Cells 9 (2): 131–42. PMID 15009091. 
  • Abbady AQ, Bronner C, Trotzier MA, et al. (2004). "ICBP90 expression is downregulated in apoptosis-induced Jurkat cells.". Ann. N. Y. Acad. Sci. 1010: 300–3. PMID 15033738. 
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Trotzier MA, Bronner C, Bathami K, et al. (2004). "Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression.". Biochem. Biophys. Res. Commun. 319 (2): 590–5. doi:10.1016/j.bbrc.2004.05.028. PMID 15178447. 
  • Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.". Oncogene 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834. 
  • Abbady AQ, Bronner C, Bathami K, et al. (2005). "TCR pathway involves ICBP90 gene down-regulation via E2F binding sites.". Biochem. Pharmacol. 70 (4): 570–9. doi:10.1016/j.bcp.2005.05.012. PMID 15964557. 
  • Jeanblanc M, Mousli M, Hopfner R, et al. (2005). "The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle.". Oncogene 24 (49): 7337–45. doi:10.1038/sj.onc.1208878. PMID 16007129. 
  • Jenkins Y, Markovtsov V, Lang W, et al. (2006). "Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth.". Mol. Biol. Cell 16 (12): 5621–9. doi:10.1091/mbc.E05-03-0194. PMID 16195352. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
  • Muto M, Fujimori A, Nenoi M, et al. (2006). "Isolation and Characterization of a Novel Human Radiosusceptibility Gene, NP95.". Radiat. Res. 166 (5): 723–33. doi:10.1667/RR0459.1. PMID 17067204. 
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