UGT8

From Wikipedia, the free encyclopedia

UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)

Identifiers

External IDs

OMIM: 601291 MGI: 109522 HomoloGene: 20715

Gene ontology
Molecular Function:	• 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity • UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity • transferase activity, transferring hexosyl groups
Cellular Component:	• endoplasmic reticulum • microsome • membrane • integral to membrane
Biological Process:	• glycosphingolipid biosynthetic process • central nervous system development • peripheral nervous system development • metabolic process

Orthologs

Human

Mouse

Refseq

NM_003360 (mRNA)
NP_003351 (protein)

NM_011674 (mRNA)
NP_035804 (protein)

Location

Chr 4: 115.74 - 115.82 Mb

Chr 3: 125.86 - 125.93 Mb

Pubmed search

[1]

[2]

UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase), also known as UGT8, is a human gene.^[1]

Galactocerebrosides are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system and are also present in small amounts in kidney. The key enzymatic step in the biosynthesis of galactocerebrosides consists of the transfer of galactose to ceramide catalyzed by UDP-galactose ceramide galactosyltransferase (CGT, EC 2.4.1.45). The enzyme encoded by the CGT gene is the first involved in complex lipid biosynthesis in the myelinating oligodendrocyte.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: UGT8 UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase).

[edit] Further reading

Yahi N, Spitalnik SL, Stefano KA, et al. (1994). "Interferon-gamma decreases cell surface expression of galactosyl ceramide, the receptor for HIV-1 GP120 on human colonic epithelial cells.". Virology 204 (2): 550–7. doi:10.1006/viro.1994.1568. PMID 7941321.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Bhat S, Mettus RV, Reddy EP, et al. (1993). "The galactosyl ceramide/sulfatide receptor binding region of HIV-1 gp120 maps to amino acids 206-275.". AIDS Res. Hum. Retroviruses 9 (2): 175–81. PMID 8457384.
Bosio A, Binczek E, Le Beau MM, et al. (1996). "The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26.". Genomics 34 (1): 69–75. doi:10.1006/geno.1996.0242. PMID 8661025.
Kapitonov D, Yu RK (1997). "Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA.". Biochem. Biophys. Res. Commun. 232 (2): 449–53. doi:10.1006/bbrc.1997.6240. PMID 9125199.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Sprong H, Kruithof B, Leijendekker R, et al. (1998). "UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum.". J. Biol. Chem. 273 (40): 25880–8. PMID 9748263.
Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8.". J. Hum. Genet. 47 (10): 505–10. doi:10.1007/s100380200075. PMID 12376738.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sprong H, Degroote S, Nilsson T, et al. (2004). "Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum.". Mol. Biol. Cell 14 (8): 3482–93. doi:10.1091/mbc.E03-03-0130. PMID 12925779.
Tencomnao T, Kapitonov D, Bieberich E, Yu RK (2005). "Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE.". Glycoconj. J. 20 (5): 339–51. doi:10.1023/B:GLYC.0000033630.58533.16. PMID 15229398.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lebea PJ, Pretorius PJ (2006). "The molecular relationship between deficient UDP-galactose uridyl transferase (GALT) and ceramide galactosyltransferase (CGT) enzyme function: a possible cause for poor long-term prognosis in classic galactosemia.". Med. Hypotheses 65 (6): 1051–7. doi:10.1016/j.mehy.2005.06.025. PMID 16125333.