UGT2B17

From Wikipedia, the free encyclopedia

UDP glucuronosyltransferase 2 family, polypeptide B17

Identifiers

External IDs

OMIM: 601903 MGI: 1919023 HomoloGene: 68144

Gene ontology
Molecular Function:	• glucuronosyltransferase activity • transferase activity, transferring hexosyl groups
Cellular Component:	• membrane fraction • endoplasmic reticulum • microsome • membrane • integral to membrane
Biological Process:	• metabolic process • steroid metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

XM_001125683 (mRNA)
XP_001125683 (protein)

NM_152811 (mRNA)
NP_690024 (protein)

Location

Chr 4: 69.09 - 69.12 Mb

Chr 5: 87.99 - 88 Mb

Pubmed search

[1]

[2]

UDP glucuronosyltransferase 2 family, polypeptide B17, also known as UGT2B17, is a human gene.^[1]

UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17.

[edit] Further reading

Chung LW, Coffey DS (1978). "Androgen glucuronide. II. DIfferences in its formation by human normal and benign hyperplastic prostates.". Investigative urology 15 (5): 385-8. PMID 76619.
Moghissi E, Ablan F, Horton R (1984). "Origin of plasma androstanediol glucuronide in men.". J. Clin. Endocrinol. Metab. 59 (3): 417-21. PMID 6746859.
Beaulieu M, Lévesque E, Hum DW, Bélanger A (1996). "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids.". J. Biol. Chem. 271 (37): 22855-62. PMID 8798464.
Beaulieu M, Lévesque E, Tchernof A, et al. (1997). "Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme.". DNA Cell Biol. 16 (10): 1143-54. PMID 9364925.
Collier AC, Ganley NA, Tingle MD, et al. (2002). "UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term.". Biochem. Pharmacol. 63 (3): 409-19. PMID 11853692.
Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.". Endocr. Res. 30 (4): 717-25. PMID 15666817.
Lazarus P, Zheng Y, Aaron Runkle E, et al. (2006). "Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes.". Pharmacogenet. Genomics 15 (11): 769-78. PMID 16220109.
Jakobsson J, Ekström L, Inotsume N, et al. (2006). "Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism.". J. Clin. Endocrinol. Metab. 91 (2): 687-93. doi:10.1210/jc.2005-1643. PMID 16332934.
Park J, Chen L, Ratnashinge L, et al. (2006). "Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men.". Cancer Epidemiol. Biomarkers Prev. 15 (8): 1473-8. doi:10.1158/1055-9965.EPI-06-0141. PMID 16896035.
Gallagher CJ, Muscat JE, Hicks AN, et al. (2007). "The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer.". Cancer Epidemiol. Biomarkers Prev. 16 (4): 823-8. doi:10.1158/1055-9965.EPI-06-0823. PMID 17416778.
Park JY, Tanner JP, Sellers TA, et al. (2007). "Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.". Urology 70 (2): 374-9. doi:10.1016/j.urology.2007.03.001. PMID 17826523.
Chouinard S, Barbier O, Bélanger A (2008). "UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.". J. Biol. Chem. 282 (46): 33466-74. doi:10.1074/jbc.M703370200. PMID 17848572.