UGT2B10

From Wikipedia, the free encyclopedia

UDP glucuronosyltransferase 2 family, polypeptide B10

PDB rendering based on 2o6l.

Available structures: 2o6l

Identifiers

Symbol(s)

UGT2B10; MGC142209

External IDs

OMIM: 600070 MGI: 2140962 HomoloGene: 68157

Gene ontology
Molecular Function:	• glucuronosyltransferase activity
Cellular Component:	• endoplasmic reticulum • microsome • membrane • integral to membrane
Biological Process:	• lipid metabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001075 (mRNA)
NP_001066 (protein)

NM_153598 (mRNA)
NP_705826 (protein)

Location

Chr 4: 69.72 - 69.73 Mb

Chr 5: 87.96 - 87.98 Mb

Pubmed search

[1]

[2]

UDP glucuronosyltransferase 2 family, polypeptide B10, also known as UGT2B10, is a human gene.^[1]

[edit] References

^ Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10.

[edit] Further reading

Chen G, Dellinger RW, Gallagher CJ, et al.. "Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines.". Pharmacogenet. Genomics 18 (3): 181-91. doi:10.1097/FPC.0b013e3282f4dbdd. PMID 18300939.
Chen G, Blevins-Primeau AS, Dellinger RW, et al. (2007). "Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.". Cancer Res. 67 (19): 9024-9. doi:10.1158/0008-5472.CAN-07-2245. PMID 17909004.
Kaivosaari S, Toivonen P, Hesse LM, et al. (2007). "Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.". Mol. Pharmacol. 72 (3): 761-8. doi:10.1124/mol.107.037093. PMID 17576790.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.". J. Biol. Chem. 275 (46): 36164-71. doi:10.1074/jbc.M002180200. PMID 10748067.
Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.". Biochem. J. 338 ( Pt 2): 489-98. PMID 10024527.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.". Biochem. Biophys. Res. Commun. 194 (1): 496-503. doi:10.1006/bbrc.1993.1847. PMID 8333863.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.