UGT1A10

From Wikipedia, the free encyclopedia

UDP glucuronosyltransferase 1 family, polypeptide A10

Identifiers

UGT1A10; UDPGT; UGT1J; UGT1H; UGT1*7; UGT1G; HLUGP4; LUGP4; UGT1AI

External IDs

OMIM: 606435 MGI: 3580642 HomoloGene: 80236

Gene ontology
Molecular Function:	• glucuronosyltransferase activity • transferase activity, transferring hexosyl groups • UDP-glycosyltransferase activity • transferase activity
Cellular Component:	• cellular_component • endoplasmic reticulum • microsome • membrane • integral to membrane
Biological Process:	• metabolic process • xenobiotic metabolic process

Orthologs

Human

Mouse

Entrez

54575

394430

Refseq

NM_019075 (mRNA)
NP_061948 (protein)

XM_001004717 (mRNA)
XP_001004717 (protein)

Pubmed search

[1]

[2]

UDP glucuronosyltransferase 1 family, polypeptide A10, also known as UGT1A10, is a human gene.^[1]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.^[1]

[edit] References

^ ^a ^b Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10.

[edit] Further reading

Mackenzie PI, Owens IS, Burchell B, et al. (1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.". Pharmacogenetics 7 (4): 255-69. PMID 9295054.
Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease.". Annu. Rev. Pharmacol. Toxicol. 40: 581-616. doi:10.1146/annurev.pharmtox.40.1.581. PMID 10836148.
Tukey RH, Strassburg CP (2001). "Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract.". Mol. Pharmacol. 59 (3): 405-14. PMID 11179432.
King CD, Rios GR, Green MD, Tephly TR (2001). "UDP-glucuronosyltransferases.". Curr. Drug Metab. 1 (2): 143-61. PMID 11465080.
Harding D, Jeremiah SJ, Povey S, Burchell B (1990). "Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1.". Ann. Hum. Genet. 54 (Pt 1): 17-21. PMID 2108603.
van Es HH, Bout A, Liu J, et al. (1993). "Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.". Cytogenet. Cell Genet. 63 (2): 114-6. PMID 8467709.
Strassburg CP, Oldhafer K, Manns MP, Tukey RH (1997). "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.". Mol. Pharmacol. 52 (2): 212-20. PMID 9271343.
Mojarrabi B, Mackenzie PI (1997). "The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid.". Biochem. Biophys. Res. Commun. 238 (3): 775-8. doi:10.1006/bbrc.1997.7388. PMID 9325166.
Mojarrabi B, Mackenzie PI (1998). "Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon.". Biochem. Biophys. Res. Commun. 247 (3): 704-9. doi:10.1006/bbrc.1998.8843. PMID 9647757.
Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.". Biochem. J. 338 ( Pt 2): 489-98. PMID 10024527.
Cheng Z, Radominska-Pandya A, Tephly TR (1999). "Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10.". Drug Metab. Dispos. 27 (10): 1165-70. PMID 10497143.
Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.". J. Biol. Chem. 275 (46): 36164-71. doi:10.1074/jbc.M002180200. PMID 10748067.
Gong QH, Cho JW, Huang T, et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.". Pharmacogenetics 11 (4): 357-68. PMID 11434514.
Zheng Z, Fang JL, Lazarus P (2002). "Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues.". Drug Metab. Dispos. 30 (4): 397-403. PMID 11901093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Jinno H, Saeki M, Tanaka-Kagawa T, et al. (2003). "Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10.". Drug Metab. Dispos. 31 (5): 528-32. PMID 12695339.