UGDH

From Wikipedia, the free encyclopedia

UDP-glucose dehydrogenase

Identifiers

UGDH; GDH; UDP-GlcDH; UDPGDH; UGD

External IDs

OMIM: 603370 MGI: 1306785 HomoloGene: 2520

Gene ontology
Molecular Function:	• UDP-glucose 6-dehydrogenase activity • electron carrier activity
Biological Process:	• UDP-glucose metabolic process • glycosaminoglycan biosynthetic process • UDP-glucuronate biosynthetic process • electron transport • gastrulation (sensu Mammalia)

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003359 (mRNA)
NP_003350 (protein)

NM_009466 (mRNA)
NP_033492 (protein)

Location

Chr 4: 39.18 - 39.21 Mb

n/a

Pubmed search

[1]

[2]

UDP-glucose dehydrogenase, also known as UGDH, is a human gene.^[1]

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.^[1]

[edit] References

^ ^a ^b Entrez Gene: UGDH UDP-glucose dehydrogenase.

[edit] Further reading

Spicer AP, Kaback LA, Smith TJ, Seldin MF (1998). "Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes.". J. Biol. Chem. 273 (39): 25117-24. PMID 9737970.
Peng HL, Lou MD, Chang ML, Chang HY (1999). "cDNA cloning and expression analysis of the human UDPglucose dehydrogenase.". Proc. Natl. Sci. Counc. Repub. China B 22 (4): 166-72. PMID 9850599.
Marcu O, Stathakis DG, Marsh JL (2000). "Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping.". Cytogenet. Cell Genet. 86 (3-4): 244-5. PMID 10575217.
Bontemps Y, Maquart FX, Wegrowski Y (2000). "Human UDP-glucose dehydrogenase gene: complete cloning and transcription start mapping.". Biochem. Biophys. Res. Commun. 275 (3): 981-5. doi:10.1006/bbrc.2000.3389. PMID 10973831.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bontemps Y, Vuillermoz B, Antonicelli F, et al. (2003). "Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia.". J. Biol. Chem. 278 (24): 21566-75. doi:10.1074/jbc.M209366200. PMID 12682078.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Sommer BJ, Barycki JJ, Simpson MA (2004). "Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations.". J. Biol. Chem. 279 (22): 23590-6. doi:10.1074/jbc.M401928200. PMID 15044486.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Huh JW, Yoon HY, Lee HJ, et al. (2004). "Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase.". J. Biol. Chem. 279 (36): 37491-8. doi:10.1074/jbc.M404234200. PMID 15247292.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Huh JW, Lee HJ, Choi MM, et al. (2005). "Identification of a UDP-glucose-binding site of human UDP-glucose dehydrogenase by photoaffinity labeling and cassette mutagenesis.". Bioconjug. Chem. 16 (3): 710-6. doi:10.1021/bc0500387. PMID 15898741.
Vatsyayan J, Peng HL, Chang HY (2005). "Analysis of human UDP-glucose dehydrogenase gene promoter: identification of an Sp1 binding site crucial for the expression of the large transcript.". J. Biochem. 137 (6): 703-9. doi:10.1093/jb/mvi082. PMID 16002992.
Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary.". J. Mol. Med. 83 (10): 812-21. doi:10.1007/s00109-005-0676-y. PMID 16021519.
Vatsyayan J, Lin CT, Peng HL, Chang HY (2006). "Identification of a cis-acting element responsible for negative regulation of the human UDP-glucose dehydrogenase gene expression.". Biosci. Biotechnol. Biochem. 70 (2): 401-10. PMID 16495656.
Huh JW, Robinson RC, Lee HS, et al. (2006). "Expression, purification, crystallization, and preliminary X-Ray analysis of the human UDP-glucose dehydrogenase.". Protein Pept. Lett. 13 (8): 859-62. PMID 17073734.
Easley KE, Sommer BJ, Boanca G, et al. (2007). "Characterization of human UDP-glucose dehydrogenase reveals critical catalytic roles for lysine 220 and aspartate 280.". Biochemistry 46 (2): 369-78. doi:10.1021/bi061537d. PMID 17209547.