UDP-sulfoquinovose synthase

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In enzymology, an UDP-sulfoquinovose synthase (EC 3.13.1.1) is an enzyme that catalyzes the chemical reaction

UDP-glucose + sulfite $\rightleftharpoons$ UDP-6-sulfoquinovose + H₂O

Thus, the two substrates of this enzyme are UDP-glucose and sulfite, whereas its two products are UDP-6-sulfoquinovose and H₂O.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-sulfur bonds. The systematic name of this enzyme class is UDP-6-sulfo-6-deoxyglucose sulfohydrolase. Other names in common use include sulfite:UDP-glucose sulfotransferase, and UDPsulfoquinovose synthase. This enzyme participates in nucleotide sugars metabolism and glycerolipid metabolism.

[edit] References

IUBMB entry for 3.13.1.1
BRENDA references for 3.13.1.1 (Recommended.)
PubMed references for 3.13.1.1
PubMed Central references for 3.13.1.1
Google Scholar references for 3.13.1.1
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Essigmann B, Hespenheide BM, Kuhn LA, Benning C (1999). "Prediction of the active-site structure and NAD(+) binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis". Arch. Biochem. Biophys. 369: 30–41. doi:10.1006/abbi.1999.1344. PMID 10462438.
Mulichak AM, Theisen MJ, Essigmann B, Benning C, Garavito RM (1999). "Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose". Proc. Natl. Acad. Sci. U. S. A. 96: 13097–102. doi:10.1073/pnas.96.23.13097. PMID 10557279.
Sanda S, Leustek T, Theisen MJ, Garavito RM, Benning C (2001). "Recombinant Arabidopsis SQD1 converts udp-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro". J. Biol. Chem. 276: 3941–6. doi:10.1074/jbc.M008200200. PMID 11073956.