UDP-glucuronate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, an UDP-glucuronate decarboxylase (EC 4.1.1.35) is an enzyme that catalyzes the chemical reaction

UDP-D-glucuronate UDP-D-xylose + CO₂

Hence, this enzyme has one substrate, UDP-D-glucuronate, and two products, UDP-D-xylose and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming). Other names in common use include uridine-diphosphoglucuronate decarboxylase, and UDP-D-glucuronate carboxy-lyase. This enzyme participates in starch and sucrose metabolism and nucleotide sugars metabolism. It employs one cofactor, NAD+.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2B69 and 2BLL.

[edit] References

• IUBMB entry for 4.1.1.35
• BRENDA references for 4.1.1.35 (Recommended.)
• PubMed references for 4.1.1.35
• PubMed Central references for 4.1.1.35
• Google Scholar references for 4.1.1.35
• Ankel H and Feingold DS (1965). "Biosynthesis of uridine diphosphate D-xylose. 1. Uridine diphosphate glucuronate carboxy-lyase of wheat germ". Biochemistry 4: 2468–2475. doi:10.1021/bi00887a028. 

[edit] External links

The CAS registry number for this enzyme class is 9024-68-4.

• IUBMB entry for 4.1.1.35

• KEGG entry for 4.1.1.35

• BRENDA entry for 4.1.1.35

• NiceZyme view of 4.1.1.35

• EC2PDB: PDB structures for 4.1.1.35

• PRIAM entry for 4.1.1.35

• PUMA2 entry for 4.1.1.35

• IntEnz: Integrated Enzyme entry for 4.1.1.35

• MetaCyc entry for 4.1.1.35

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0048040: UDP-glucuronate decarboxylase

• AMIGO entry for GO code 0048040: UDP-glucuronate decarboxylase