UDP-glucuronate 5'-epimerase

From Wikipedia, the free encyclopedia

In enzymology, an UDP-glucuronate 5'-epimerase (EC 5.1.3.12) is an enzyme that catalyzes the chemical reaction

UDP-glucuronate UDP-L-iduronate

Hence, this enzyme has one substrate, UDP-glucuronate, and one product, UDP-L-iduronate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-glucuronate 5'-epimerase. Other names in common use include uridine diphosphoglucuronate 5'-epimerase, UDP-glucuronic acid 5'-epimerase, and C-5-uronosyl epimerase. This enzyme participates in nucleotide sugars metabolism. It employs one cofactor, NAD+.

[edit] References

• IUBMB entry for 5.1.3.12
• BRENDA references for 5.1.3.12 (Recommended.)
• PubMed references for 5.1.3.12
• PubMed Central references for 5.1.3.12
• Google Scholar references for 5.1.3.12
• Jacobson B and Davidson EA (1962). "Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase". J. Biol. Chem. 237: 638–642. 

[edit] External links

The CAS registry number for this enzyme class is 37318-38-0.

• IUBMB entry for 5.1.3.12

• KEGG entry for 5.1.3.12

• BRENDA entry for 5.1.3.12

• NiceZyme view of 5.1.3.12

• EC2PDB: PDB structures for 5.1.3.12

• PRIAM entry for 5.1.3.12

• PUMA2 entry for 5.1.3.12

• IntEnz: Integrated Enzyme entry for 5.1.3.12

• MetaCyc entry for 5.1.3.12

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050379: UDP-glucuronate 5'-epimerase

• AMIGO entry for GO code 0050379: UDP-glucuronate 5'-epimerase