UDP-glucose 4-epimerase

From Wikipedia, the free encyclopedia

In enzymology, an UDP-glucose 4-epimerase (EC 5.1.3.2) is an enzyme that catalyzes the chemical reaction

UDP-glucose UDP-galactose

Hence, this enzyme has one substrate, UDP-glucose, and one product, UDP-galactose.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-glucose 4-epimerase. Other names in common use include UDP-galactose 4-epimerase, uridine diphosphoglucose epimerase, galactowaldenase, UDPG-4-epimerase, uridine diphosphate galactose 4-epimerase, uridine diphospho-galactose-4-epimerase, UDP-glucose epimerase, UDP-galactose 4-epimerase, 4-epimerase, UDPG-4-epimerase, uridine diphosphoglucose 4-epimerase, uridine diphosphate glucose 4-epimerase, and UDP-D-galactose 4-epimerase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism. It employs one cofactor, NAD+.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 30 structures have been solved for this class of enzymes, with PDB accession codes 1A9Y, 1A9Z, 1EK5, 1EK6, 1GY8, 1HZJ, 1I3K, 1I3L, 1I3M, 1I3N, 1KVQ, 1KVR, 1KVS, 1KVT, 1KVU, 1LRJ, 1LRK, 1LRL, 1NAH, 1NAI, 1UDA, 1UDB, 1UDC, 1XEL, 1Z45, 2C20, 2CNB, 2P5U, 2P5Y, and 2UDP.

[edit] References

• IUBMB entry for 5.1.3.2
• BRENDA references for 5.1.3.2 (Recommended.)
• PubMed references for 5.1.3.2
• PubMed Central references for 5.1.3.2
• Google Scholar references for 5.1.3.2
• LELOIR LF (1953). "Enzymic isomerization and related processes". Adv. Enzymol. Relat. Subj. Biochem. 14: 193–218. PMID 13057717. 
• Maxwell ES and de Robichon-Szulmajster H (1960). "Purification of uridine diphosphate galactose-4-epimerase from yeast and the identification of protein-bound diphosphopyridine nucleotide". J. Biol. Chem. 235: 308–312. 
• Wilson DB and Hogness DS (1964). "The enzymes of the galactose operon in Escherichia coli. I Purification and characterization of uridine diphosphogalactose 4-epimerase". J. Biol. Chem. 239: 2469–2481. 

[edit] External links

The CAS registry number for this enzyme class is 9032-89-7.

• IUBMB entry for 5.1.3.2

• KEGG entry for 5.1.3.2

• BRENDA entry for 5.1.3.2

• NiceZyme view of 5.1.3.2

• EC2PDB: PDB structures for 5.1.3.2

• PRIAM entry for 5.1.3.2

• PUMA2 entry for 5.1.3.2

• IntEnz: Integrated Enzyme entry for 5.1.3.2

• MetaCyc entry for 5.1.3.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003978: UDP-glucose 4-epimerase

• AMIGO entry for GO code 0003978: UDP-glucose 4-epimerase