UDP-glucose 4,6-dehydratase

From Wikipedia, the free encyclopedia

In enzymology, an UDP-glucose 4,6-dehydratase (EC 4.2.1.76) is an enzyme that catalyzes the chemical reaction

UDP-glucose UDP-4-dehydro-6-deoxy-D-glucose + H₂O

Hence, this enzyme has one substrate, UDP-glucose, and two products, UDP-4-dehydro-6-deoxy-D-glucose and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include UDP-D-glucose-4,6-hydrolyase, UDP-D-glucose oxidoreductase, and UDP-glucose 4,6-hydro-lyase. This enzyme participates in nucleotide sugars metabolism.

[edit] References

• IUBMB entry for 4.2.1.76
• BRENDA references for 4.2.1.76 (Recommended.)
• PubMed references for 4.2.1.76
• PubMed Central references for 4.2.1.76
• Google Scholar references for 4.2.1.76
• Kamsteeg J, Van Brederode J, Van Nigtevecht G (1978). "The formation of UDP-L-rhamnose from UDP-D-glucose by an enzyme preparation of red campion (Silene dioica (L) Clairv) leaves". FEBS. Lett. 91: 281–4. PMID 680134. 

[edit] External links

The CAS registry number for this enzyme class is 68189-53-7.

• IUBMB entry for 4.2.1.76

• KEGG entry for 4.2.1.76

• BRENDA entry for 4.2.1.76

• NiceZyme view of 4.2.1.76

• EC2PDB: PDB structures for 4.2.1.76

• PRIAM entry for 4.2.1.76

• PUMA2 entry for 4.2.1.76

• IntEnz: Integrated Enzyme entry for 4.2.1.76

• MetaCyc entry for 4.2.1.76

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050377: UDP-glucose 4,6-dehydratase

• AMIGO entry for GO code 0050377: UDP-glucose 4,6-dehydratase