UDP-N-acetylglucosamine diphosphorylase

From Wikipedia, the free encyclopedia

In enzymology, an UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) is an enzyme that catalyzes the chemical reaction

UTP + N-acetyl-alpha-D-glucosamine 1-phosphate diphosphate + UDP-N-acetyl-D-glucosamine

Thus, the two substrates of this enzyme are UTP and N-acetyl-alpha-D-glucosamine 1-phosphate, whereas its two products are diphosphate and UDP-N-acetyl-D-glucosamine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase. Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate, uridylyltransferase, UDP-GlcNAc pyrophosphorylase, GlmU uridylyltransferase, Acetylglucosamine 1-phosphate uridylyltransferase, UDP-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and acetylglucosamine 1-phosphate uridylyltransferase. This enzyme participates in aminosugars metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1FWY, 1FXJ, 1G95, 1G97, 1HM0, 1HM8, 1HM9, 1HV9, 1JVD, 1JVG, 1VM8, 2NPO, 2OI5, 2OI6, 2OI7, 2YQC, 2YQH, 2YQJ, and 2YQS.

[edit] References

• IUBMB entry for 2.7.7.23
• BRENDA references for 2.7.7.23 (Recommended.)
• PubMed references for 2.7.7.23
• PubMed Central references for 2.7.7.23
• Google Scholar references for 2.7.7.23
• Pattabiramin TN and Bachhawat BK (1961). "Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep brain". Biochim. Biophys. Acta 50: 129–134. doi:10.1016/0006-3002(61)91068-X. 
• Strominger JL and Smith MS (1959). "Uridine diphosphoacetylglucosamine pyrophosphorylase". J. Biol. Chem. 234: 1822–1827. 

[edit] External links

The CAS registry number for this enzyme class is 9023-06-7.

• IUBMB entry for 2.7.7.23

• KEGG entry for 2.7.7.23

• BRENDA entry for 2.7.7.23

• NiceZyme view of 2.7.7.23

• EC2PDB: PDB structures for 2.7.7.23

• PRIAM entry for 2.7.7.23

• PUMA2 entry for 2.7.7.23

• IntEnz: Integrated Enzyme entry for 2.7.7.23

• MetaCyc entry for 2.7.7.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003977: UDP-N-acetylglucosamine diphosphorylase

• AMIGO entry for GO code 0003977: UDP-N-acetylglucosamine diphosphorylase