UDP-N-acetylglucosamine 4-epimerase

From Wikipedia, the free encyclopedia

In enzymology, an UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine $\rightleftharpoons$ UDP-N-acetyl-D-galactosamine

Hence, this enzyme has one substrate, UDP-N-acetyl-D-glucosamine, and one product, UDP-N-acetyl-D-galactosamine.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine 4-epimerase. Other names in common use include UDP acetylglucosamine epimerase, uridine diphosphoacetylglucosamine epimerase, uridine diphosphate N-acetylglucosamine-4-epimerase, and uridine 5'-diphospho-N-acetylglucosamine-4-epimerase. This enzyme participates in aminosugars metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1SB8 and 1SB9.

[edit] References

IUBMB entry for 5.1.3.7
BRENDA references for 5.1.3.7 (Recommended.)
PubMed references for 5.1.3.7
PubMed Central references for 5.1.3.7
Google Scholar references for 5.1.3.7
GLASER L (1959). "The biosynthesis of N-acetylgalactosamine". J. Biol. Chem. 234: 2801–5. PMID 13828347.
Kornfeld S and Glaser L (1962). "The synthesis of thymidine-linked sugars. V. Thymidine diphosphate-amino sugars". J. Biol. Chem. 237: 3052–3059.