UDP-N-acetylglucosamine 1-carboxyvinyltransferase

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Please improve this article if you can. (December 2007)

In enzymology, an UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine $\rightleftharpoons$ phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine

Thus, the two substrates of this enzyme are phosphoenolpyruvate and UDP-N-acetyl-D-glucosamine, whereas its two products are phosphate and UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase.^[1] This enzyme participates in amino sugars metabolism and glycan biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1A2N, 1DLG, 1EJC, 1EJD, 1EYN, 1NAW, 1Q3G, 1RYW, 1UAE, and 1YBG.

[edit] References

^ Other names in common use include MurA transferase, UDP-N-acetylglucosamine 1-carboxyvinyl-transferase, UDP-N-acetylglucosamine enoylpyruvyltransferase, enoylpyruvate transferase, phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase, phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase, phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase, phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase, phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase, pyruvate-UDP-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetyl-glucosamine transferase, and pyruvic-uridine diphospho-N-acetylglucosaminyltransferase.

IUBMB entry for 2.5.1.7
BRENDA references for 2.5.1.7 (Recommended.)
PubMed references for 2.5.1.7
PubMed Central references for 2.5.1.7
Google Scholar references for 2.5.1.7
Gunetileke KG, Anwar RA (1968). "Biosynthesis of uridine diphospho-N-acetylmuramic acid. II Purification and properties of pyruvate-uridine diphospho-N-acetylglucosamine transferase and characterization of uridine diphospho-N-acetylenopyruvylglucosamine". J. Biol. Chem. 243: 5770–8. PMID 5699062.
Zemell RI, Anwar RA (1975). "Pyruvate-uridine diphospho-N-acetylglucosamine transferase Purification to homogeneity and feedback inhibition". J. Biol. Chem. 250: 3185–92. PMID 1123336.
van Heijenoort J (2001). "Recent advances in the formation of the bacterial peptidoglycan monomer unit". Nat. Prod. Rep. 18: 503–19. PMID 11699883.