UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase

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In enzymology, an UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase (EC 2.7.8.17) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose $\rightleftharpoons$ UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and lysosomal-enzyme D-mannose, whereas its two products are UMP and lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups transferases for other substituted phosphate groups. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase. Other names in common use include UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase, UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase, uridine diphosphoacetylglucosamine-lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase, uridine diphosphoacetylglucosamine-glycoprotein acetylglucosamine-1-phosphotransferase, lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase, UDP-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase, UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase, UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase, and UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase.

[edit] References

IUBMB entry for 2.7.8.17
BRENDA references for 2.7.8.17 (Recommended.)
PubMed references for 2.7.8.17
PubMed Central references for 2.7.8.17
Google Scholar references for 2.7.8.17
Reitman ML, Kornfeld S (1981). "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes". J. Biol. Chem. 256: 4275–81. PMID 6452459.
Reitman ML, Kornfeld S (1981). "Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes". J. Biol. Chem. 256: 11977–80. PMID 6457829.
Waheed A, Hasilik A, von Figura K (1982). "UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme". J. Biol. Chem. 257: 12322–31. PMID 6288715.
Waheed A, Pohlmann R, Hasilik A, von Figura K (1981). "Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes". J. Biol. Chem. 256: 4150–2. PMID 6260788.