UCP3

From Wikipedia, the free encyclopedia

Uncoupling protein 3 (mitochondrial, proton carrier)

Identifiers

UCP3; SLC25A9

External IDs

OMIM: 602044 MGI: 1099787 HomoloGene: 2517

Gene ontology
Molecular Function:	• transporter activity • binding • oxidative phosphorylation uncoupler activity
Cellular Component:	• membrane fraction • mitochondrion • mitochondrial inner membrane • membrane • integral to membrane
Biological Process:	• response to superoxide • generation of precursor metabolites and energy • lipid metabolic process • fatty acid metabolic process • transport • mitochondrial transport • respiratory gaseous exchange • proton transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003356 (mRNA)
NP_003347 (protein)

NM_009464 (mRNA)
NP_033490 (protein)

Location

Chr 11: 73.39 - 73.4 Mb

Chr 7: 100.35 - 100.36 Mb

Pubmed search

[1]

[2]

Uncoupling protein 3 (mitochondrial, proton carrier), also known as UCP3, is a human gene.

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene has tissue-specific transcription initiation with other transcription initiation sites upstream of SM-1 (major skeletal muscle site). Chromosomal order is 5'-UCP3-UCP2-3'. Two splice variants have been found for this gene.^[1]

[edit] See also

Uncoupling protein

[edit] References

^ Entrez Gene: UCP3 uncoupling protein 3 (mitochondrial, proton carrier).

[edit] Further reading

Ricquier D, Bouillaud F (2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP.". Biochem. J. 345 Pt 2: 161–79. PMID 10620491.
Muzzin P (2002). "The uncoupling proteins.". Ann. Endocrinol. (Paris) 63 (2 Pt 1): 106–10. PMID 11994670.
Boss O, Samec S, Paoloni-Giacobino A, et al. (1997). "Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.". FEBS Lett. 408 (1): 39–42. PMID 9180264.
Vidal-Puig A, Solanes G, Grujic D, et al. (1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.". Biochem. Biophys. Res. Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.
Gong DW, He Y, Karas M, Reitman M (1997). "Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin.". J. Biol. Chem. 272 (39): 24129–32. PMID 9305858.
Solanes G, Vidal-Puig A, Grujic D, et al. (1997). "The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.". J. Biol. Chem. 272 (41): 25433–6. PMID 9325252.
Boss O, Giacobino JP, Muzzin P (1998). "Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13.". Genomics 47 (3): 425–6. doi:10.1006/geno.1997.5135. PMID 9480760.
Urhammer SA, Dalgaard LT, Sørensen TI, et al. (1998). "Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.". Diabetologia 41 (2): 241–4. PMID 9498661.
Argyropoulos G, Brown AM, Willi SM, et al. (1998). "Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.". J. Clin. Invest. 102 (7): 1345–51. PMID 9769326.
Acín A, Rodriguez M, Rique H, et al. (1999). "Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene.". Biochem. Biophys. Res. Commun. 258 (2): 278–83. PMID 10329378.
Vidal-Puig AJ, Grujic D, Zhang CY, et al. (2000). "Energy metabolism in uncoupling protein 3 gene knockout mice.". J. Biol. Chem. 275 (21): 16258–66. doi:10.1074/jbc.M910179199. PMID 10748196.
Jezek P, Urbánková E (2000). "Specific sequence of motifs of mitochondrial uncoupling proteins.". IUBMB Life 49 (1): 63–70. PMID 10772343.
Pierrat B, Ito M, Hinz W, et al. (2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family.". Eur. J. Biochem. 267 (9): 2680–7. PMID 10785390.
Clapham JC, Arch JR, Chapman H, et al. (2000). "Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.". Nature 406 (6794): 415–8. doi:10.1038/35019082. PMID 10935638.
Esterbauer H, Oberkofler H, Krempler F, et al. (2000). "The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents.". J. Biol. Chem. 275 (46): 36394–9. doi:10.1074/jbc.M005713200. PMID 10958796.
Lanouette CM, Chagnon YC, Rice T, et al. (2002). "Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study.". J. Appl. Physiol. 92 (3): 1111–8. doi:10.1152/japplphysiol.00726.2001. PMID 11842047.
Collins P, Bing C, McCulloch P, Williams G (2002). "Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans.". Br. J. Cancer 86 (3): 372–5. doi:10.1038/sj.bjc.6600074. PMID 11875702.
Hu X, Murphy F, Karwautz A, et al. (2002). "Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa.". Mol. Psychiatry 7 (3): 276–7. doi:10.1038/sj.mp.4001044. PMID 11920154.