UCN3

From Wikipedia, the free encyclopedia


Urocortin 3 (stresscopin)
Identifiers
Symbol(s) UCN3; SCP; SPC; MGC119002; UCNIII
External IDs OMIM: 605901 MGI: 1932970 HomoloGene: 49959
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 114131 83428
Ensembl ENSG00000178473 ENSMUSG00000044988
Uniprot Q969E3 Q0VDY5
Refseq NM_053049 (mRNA)
NP_444277 (protein)		 NM_031250 (mRNA)
NP_112540 (protein)
Location Chr 10: 5.4 - 5.41 Mb Chr 13: 3.94 - 3.94 Mb
Pubmed search [1] [2]

Urocortin 3 (stresscopin), also known as UCN3, is a human gene.[1]

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[1]

[edit] References

  1. ^ a b Entrez Gene: UCN3 urocortin 3 (stresscopin).

[edit] Further reading

  • Hauger RL, Grigoriadis DE, Dallman MF, et al. (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands.". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952. 
  • Florio P, Torres PB, Torricelli M, et al. (2006). "Human endometrium expresses urocortin II and III messenger RNA and peptides.". Fertil. Steril. 86 (6): 1766–70. doi:10.1016/j.fertnstert.2006.05.041. PMID 17074339. 
  • Imperatore A, Florio P, Torres PB, et al. (2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes.". Am. J. Obstet. Gynecol. 195 (1): 288–95. doi:10.1016/j.ajog.2005.12.048. PMID 16626608. 
  • Saruta M, Takahashi K, Suzuki T, et al. (2005). "Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions.". Peptides 26 (7): 1196–206. doi:10.1016/j.peptides.2005.01.014. PMID 15949638. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Chang CL, Hsu SY (2005). "Ancient evolution of stress-regulating peptides in vertebrates.". Peptides 25 (10): 1681–8. doi:10.1016/j.peptides.2004.05.022. PMID 15476935. 
  • Takahashi K, Totsune K, Murakami O, et al. (2004). "Expression of urocortin III/stresscopin in human heart and kidney.". J. Clin. Endocrinol. Metab. 89 (4): 1897–903. PMID 15070962. 
  • Seres J, Bornstein SR, Seres P, et al. (2004). "Corticotropin-releasing hormone system in human adipose tissue.". J. Clin. Endocrinol. Metab. 89 (2): 965–70. PMID 14764822. 
  • Chanalaris A, Lawrence KM, Stephanou A, et al. (2004). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes.". J. Mol. Cell. Cardiol. 35 (10): 1295–305. PMID 14519439. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lewis K, Li C, Perrin MH, et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMID 11416224. 
  • Hsu SY, Hsueh AJ (2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.". Nat. Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. 
 This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it.