UBTF

From Wikipedia, the free encyclopedia

Upstream binding transcription factor, RNA polymerase I

PDB rendering based on 1k99.

Available structures: 1k99, 1l8y, 1l8z, 1v63, 1v64, 1wgf

Identifiers

Symbol(s)

UBTF; NOR-90; UBF

External IDs

OMIM: 600673 MGI: 98512 HomoloGene: 7970

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase I transcription factor activity • protein binding
Cellular Component:	• nucleus • nucleolus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase I promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001076683 (mRNA)
NP_001070151 (protein)

NM_001044383 (mRNA)
NP_001037848 (protein)

Location

Chr 17: 39.64 - 39.65 Mb

Chr 11: 102.12 - 102.14 Mb

Pubmed search

[1]

[2]

Upstream binding transcription factor, RNA polymerase I, also known as UBTF, is a human gene.^[1]

Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I.

[edit] Further reading

Chan EK, Imai H, Hamel JC, Tan EM (1991). "Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor.". J. Exp. Med. 174 (5): 1239–44. PMID 1940801.
Jantzen HM, Admon A, Bell SP, Tjian R (1990). "Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.". Nature 344 (6269): 830–6. doi:10.1038/344830a0. PMID 2330041.
Bell SP, Learned RM, Jantzen HM, Tjian R (1988). "Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis.". Science 241 (4870): 1192–7. PMID 3413483.
Voit R, Kuhn A, Sander EE, Grummt I (1995). "Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF.". Nucleic Acids Res. 23 (14): 2593–9. PMID 7651819.
Hempel WM, Cavanaugh AH, Hannan RD, et al. (1996). "The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor.". Mol. Cell. Biol. 16 (2): 557–63. PMID 8552083.
Hanada K, Song CZ, Yamamoto K, et al. (1996). "RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription.". EMBO J. 15 (9): 2217–26. PMID 8641287.
Pluta AF, Earnshaw WC (1996). "Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator.". J. Biol. Chem. 271 (31): 18767–74. PMID 8702533.
Matera AG, Wu W, Imai H, et al. (1997). "Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping.". Genomics 41 (1): 135–8. doi:10.1006/geno.1997.4647. PMID 9126496.
Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB (1998). "ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes.". Chromosoma 106 (8): 493–502. PMID 9426281.
Voit R, Hoffmann M, Grummt I (1999). "Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF.". EMBO J. 18 (7): 1891–9. doi:10.1093/emboj/18.7.1891. PMID 10202152.
Liu CJ, Wang H, Lengyel P (1999). "The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription.". EMBO J. 18 (10): 2845–54. doi:10.1093/emboj/18.10.2845. PMID 10329630.
Hannan KM, Hannan RD, Smith SD, et al. (2000). "Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1.". Oncogene 19 (43): 4988–99. doi:10.1038/sj.onc.1203875. PMID 11042686.
Kalousek I, Krízková P (2001). "Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF.". Cell. Mol. Biol. (Noisy-le-grand) 46 (7): 1163–71. PMID 11075946.
Pelletier G, Stefanovsky VY, Faubladier M, et al. (2002). "Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription.". Mol. Cell 6 (5): 1059–66. PMID 11106745.
Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMID 11250903.
Seither P, Iben S, Thiry M, Grummt I (2002). "PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I.". Biol. Chem. 382 (8): 1163–70. PMID 11592397.
Voit R, Grummt I (2002). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription.". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. doi:10.1073/pnas.231071698. PMID 11698641.
Stefanovsky VY, Pelletier G, Hannan R, et al. (2002). "An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF.". Mol. Cell 8 (5): 1063–73. PMID 11741541.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Dühr S, Torres-Montaner A, Astola A, et al. (2002). "Molecular analysis of the 5' region of human ribosomal transcription factor UBF.". DNA Seq. 12 (4): 267–72. PMID 11916260.