UBQLN2

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Ubiquilin 2
PDB rendering based on 1j8c.
Available structures: 1j8c
Identifiers
Symbol(s) UBQLN2; CHAP1; CHAP1/DSK2; Dsk2; HRIHFB2157; LIC-2; N4BP4; PLIC-2; PLIC2; RIHFB2157
External IDs OMIM: 300264 MGI: 1860283 HomoloGene: 81830
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 29978 54609
Ensembl ENSG00000188021 ENSMUSG00000050148
Uniprot Q9UHD9 Q9QZM0
Refseq NM_013444 (mRNA)
NP_038472 (protein)		 NM_018798 (mRNA)
NP_061268 (protein)
Location Chr X: 56.61 - 56.61 Mb Chr X: 148.84 - 148.84 Mb
Pubmed search [1] [2]

Ubiquilin 2, also known as UBQLN2, is a human gene.[1]

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.[1]

[edit] References

  1. ^ a b Entrez Gene: UBQLN2 ubiquilin 2.

[edit] Further reading

  • Ueki N, Oda T, Kondo M, et al. (1999). "Selection system for genes encoding nuclear-targeted proteins.". Nat. Biotechnol. 16 (13): 1338-42. doi:10.1038/4315. PMID 9853615. 
  • Kaye FJ, Modi S, Ivanovska I, et al. (2000). "A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.". FEBS Lett. 467 (2-3): 348-55. PMID 10675567. 
  • Kaye FJ, Shows TB (2000). "Assignment of ubiquilin2 (UBQLN2) to human chromosome xp11. 23-->p11.1 by GeneBridge radiation hybrids.". Cytogenet. Cell Genet. 89 (1-2): 116-7. PMID 10894951. 
  • Kleijnen MF, Shih AH, Zhou P, et al. (2000). "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.". Mol. Cell 6 (2): 409-19. PMID 10983987. 
  • Murillas R, Simms KS, Hatakeyama S, et al. (2002). "Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase.". J. Biol. Chem. 277 (4): 2897-907. doi:10.1074/jbc.M110047200. PMID 11717310. 
  • Walters KJ, Kleijnen MF, Goh AM, et al. (2002). "Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.". Biochemistry 41 (6): 1767-77. PMID 11827521. 
  • Saeki Y, Sone T, Toh-e A, Yokosawa H (2002). "Identification of ubiquitin-like protein-binding subunits of the 26S proteasome.". Biochem. Biophys. Res. Commun. 296 (4): 813-9. PMID 12200120. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kleijnen MF, Alarcon RM, Howley PM (2004). "The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome.". Mol. Biol. Cell 14 (9): 3868-75. doi:10.1091/mbc.E02-11-0766. PMID 12972570. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651. 
  • Massey LK, Mah AL, Monteiro MJ (2006). "Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.". Biochem. J. 391 (Pt 3): 513-25. doi:10.1042/BJ20050491. PMID 15975090. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Ford DL, Monteiro MJ (2006). "Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.". Biochem. J. 399 (3): 397-404. doi:10.1042/BJ20060441. PMID 16813565. 
  • Kang Y, Zhang N, Koepp DM, Walters KJ (2007). "Ubiquitin receptor proteins hHR23a and hPLIC2 interact.". J. Mol. Biol. 365 (4): 1093-101. doi:10.1016/j.jmb.2006.10.056. PMID 17098253. 
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