Ubiquitin-calmodulin ligase

From Wikipedia, the free encyclopedia

In enzymology, an ubiquitin-calmodulin ligase (EC 6.3.2.21) is an enzyme that catalyzes the chemical reaction

n ATP + calmodulin + n ubiquitin n AMP + n diphosphate + (ubiquitin)n-calmodulin

The 3 substrates of this enzyme are ATP, calmodulin, and ubiquitin, whereas its 3 products are AMP, diphosphate, and (ubiquitin)n-calmodulin.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is calmodulin:ubiquitin ligase (AMP-forming). Other names in common use include ubiquityl-calmodulin synthase, ubiquitin-calmodulin synthetase, ubiquityl-calmodulin synthetase, and uCaM-synthetase.

[edit] References

• IUBMB entry for 6.3.2.21
• BRENDA references for 6.3.2.21 (Recommended.)
• PubMed references for 6.3.2.21
• PubMed Central references for 6.3.2.21
• Google Scholar references for 6.3.2.21
• Jennissen HP, Laub M (1988). "Ubiquitin-calmodulin conjugating activity from cardiac muscle". Biol. Chem. Hoppe. Seyler. 369: 1325–30. PMID 2853950. 
• Ziegenhagen R, Jennissen HP (1988). "Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase". Biol. Chem. Hoppe. Seyler. 369: 1317–24. PMID 2853949. 

[edit] External links

The CAS registry number for this enzyme class is 119632-60-9.

• IUBMB entry for 6.3.2.21

• KEGG entry for 6.3.2.21

• BRENDA entry for 6.3.2.21

• NiceZyme view of 6.3.2.21

• EC2PDB: PDB structures for 6.3.2.21

• PRIAM entry for 6.3.2.21

• PUMA2 entry for 6.3.2.21

• IntEnz: Integrated Enzyme entry for 6.3.2.21

• MetaCyc entry for 6.3.2.21

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050372: ubiquitin-calmodulin ligase

• AMIGO entry for GO code 0050372: ubiquitin-calmodulin ligase