UBE2J1

From Wikipedia, the free encyclopedia

Ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)

Identifiers

UBE2J1; CGI-76; HSPC153; HSPC205; HSU93243; MGC12555; NCUBE1; Ubc6p

External IDs

MGI: 1926245 HomoloGene: 41090

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • ligase activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016021 (mRNA)
NP_057105 (protein)

NM_019586 (mRNA)
NP_062532 (protein)

Location

Chr 6: 90.09 - 90.12 Mb

Chr 4: 33.36 - 33.38 Mb

Pubmed search

[1]

[2]

Ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast), also known as UBE2J1, is a human gene.^[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.^[1]

[edit] References

^ ^a ^b Entrez Gene: UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Lester D, Farquharson C, Russell G, Houston B (2000). "Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6.". Biochem. Biophys. Res. Commun. 269 (2): 474–80. doi:10.1006/bbrc.2000.2302. PMID 10708578.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMID 10810093.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Lenk U, Yu H, Walter J, et al. (2002). "A role for mammalian Ubc6 homologues in ER-associated protein degradation.". J. Cell. Sci. 115 (Pt 14): 3007–14. PMID 12082160.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wu CJ, Conze DB, Li X, et al. (2005). "TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination.". EMBO J. 24 (10): 1886–98. doi:10.1038/sj.emboj.7600649. PMID 15861135.
Oh RS, Bai X, Rommens JM (2006). "Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress.". J. Biol. Chem. 281 (30): 21480–90. doi:10.1074/jbc.M601843200. PMID 16720581.