UBE2H

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Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)
PDB rendering based on 1yh6.
Available structures: 1yh6
Identifiers
Symbol(s) UBE2H; E2-20K; UBC8; UBCH; UBCH2
External IDs OMIM: 601082 MGI: 104632 HomoloGene: 2510
Orthologs
Human Mouse
Entrez 7328 22214
Ensembl n/a ENSMUSG00000039159
Uniprot n/a Q3V2N4
Refseq NM_003344 (mRNA)
NP_003335 (protein)		 XM_989140 (mRNA)
XP_994234 (protein)
Location n/a Chr 6: 30.16 - 30.25 Mb
Pubmed search [1] [2]

Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast), also known as UBE2H, is a human gene.[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast).

[edit] Further reading

  • Wefes I, Mastrandrea LD, Haldeman M, et al. (1995). "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation.". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 4982–6. PMID 7761435. 
  • Kaiser P, Seufert W, Höfferer L, et al. (1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8.". J. Biol. Chem. 269 (12): 8797–802. PMID 8132613. 
  • Kaiser P, Mandl S, Schweiger M, Schneider R (1996). "Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2.". FEBS Lett. 377 (2): 193–6. PMID 8543049. 
  • Hayashida S, Yamasaki K, Asada Y, et al. (2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32.". Genomics 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
  • Vourc'h P, Martin I, Bonnet-Brilhault F, et al. (2005). "Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder.". Psychiatr. Genet. 13 (4): 221–5. doi:10.1097/01.ypg.0000084946.07075.37. PMID 14639049. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Bartee E, Mansouri M, Hovey Nerenberg BT, et al. (2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.". J. Virol. 78 (3): 1109–20. PMID 14722266. 
  • Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846. 
  • Kim HJ, Chong KH, Kang SW, et al. (2005). "Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening.". Immunol. Lett. 95 (2): 155–9. doi:10.1016/j.imlet.2004.07.001. PMID 15388255. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
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