UBE2G1

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Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)
PDB rendering based on 2awf.
Available structures: 2awf
Identifiers
Symbol(s) UBE2G1; E217K; UBC7; UBE2G
External IDs OMIM: 601569 MGI: 1914378 HomoloGene: 2508
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7326 67128
Ensembl ENSG00000132388 ENSMUSG00000020794
Uniprot P62253 Q5SPX0
Refseq NM_182682 (mRNA)
NP_872623 (protein)		 NM_025985 (mRNA)
NP_080261 (protein)
Location Chr 17: 4.12 - 4.22 Mb Chr 11: 72.42 - 72.5 Mb
Pubmed search [1] [2]

Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast), also known as UBE2G1, is a human gene.[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins.[1]

[edit] References

  1. ^ a b Entrez Gene: UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast).

[edit] Further reading

  • Chen P, Johnson P, Sommer T, et al. (1993). "Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor.". Cell 74 (2): 357–69. PMID 8393731. 
  • Watanabe TK, Kawai A, Fujiwara T, et al. (1996). "Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans.". Cytogenet. Cell Genet. 74 (1-2): 146–8. PMID 8893823. 
  • Katsanis N, Fisher EM (1998). "Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene.". Genomics 51 (1): 128–31. doi:10.1006/geno.1998.5263. PMID 9693041. 
  • Moynihan TP, Ardley HC, Nuber U, et al. (1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.". J. Biol. Chem. 274 (43): 30963–8. PMID 10521492. 
  • Huang L, Kinnucan E, Wang G, et al. (1999). "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.". Science 286 (5443): 1321–6. PMID 10558980. 
  • Joazeiro CA, Hunter T (2000). "Biochemistry. Ubiquitination--more than two to tango.". Science 289 (5487): 2061–2. PMID 11032556. 
  • Tiwari S, Weissman AM (2001). "Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s).". J. Biol. Chem. 276 (19): 16193–200. doi:10.1074/jbc.M007640200. PMID 11278356. 
  • Imai Y, Soda M, Inoue H, et al. (2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.". Cell 105 (7): 891–902. PMID 11439185. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Kim BW, Zavacki AM, Curcio-Morelli C, et al. (2004). "Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.". Mol. Endocrinol. 17 (12): 2603–12. doi:10.1210/me.2003-0082. PMID 12933904. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
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